TY - JOUR
T1 - Differential effects of systemic versus intracranial injection of opiates on central, orofacial and lower body nociception
T2 - somatotypy in bulbar analgesia systems
AU - Rosenfeld, Joel P
AU - Stocco, Susan
PY - 1980/1/1
Y1 - 1980/1/1
N2 - 1 μg morphine sulfate or 30 μg [d-Ala2]-met-enkephalin microcannulated into the bulbar nuclei reticularis gigantocellularis and paragigantocellularis produced profound analgesia for orofacial thermal nociception, while having a smaller analgesic effect on tail-flick latency, and no effect on aversive stimulation thresholds in midbrain and in the spinal trigeminal nucleus (subnucleus caudalis). Systemic morphine (10 mg/kg). producing equivalently profound orofacial analgesia, profoundly affected tail-flick latency and trigeminal nuclear stimulation thresholds, while still failing to affect to affect aversive midbrain stimulation threshold.
AB - 1 μg morphine sulfate or 30 μg [d-Ala2]-met-enkephalin microcannulated into the bulbar nuclei reticularis gigantocellularis and paragigantocellularis produced profound analgesia for orofacial thermal nociception, while having a smaller analgesic effect on tail-flick latency, and no effect on aversive stimulation thresholds in midbrain and in the spinal trigeminal nucleus (subnucleus caudalis). Systemic morphine (10 mg/kg). producing equivalently profound orofacial analgesia, profoundly affected tail-flick latency and trigeminal nuclear stimulation thresholds, while still failing to affect to affect aversive midbrain stimulation threshold.
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U2 - 10.1016/0304-3959(80)90045-7
DO - 10.1016/0304-3959(80)90045-7
M3 - Article
C2 - 7208078
AN - SCOPUS:0019121971
SN - 0304-3959
VL - 9
SP - 307
EP - 318
JO - Pain
JF - Pain
IS - 3
ER -