1 μg morphine sulfate or 30 μg [d-Ala2]-met-enkephalin microcannulated into the bulbar nuclei reticularis gigantocellularis and paragigantocellularis produced profound analgesia for orofacial thermal nociception, while having a smaller analgesic effect on tail-flick latency, and no effect on aversive stimulation thresholds in midbrain and in the spinal trigeminal nucleus (subnucleus caudalis). Systemic morphine (10 mg/kg). producing equivalently profound orofacial analgesia, profoundly affected tail-flick latency and trigeminal nuclear stimulation thresholds, while still failing to affect to affect aversive midbrain stimulation threshold.
ASJC Scopus subject areas
- Clinical Neurology
- Anesthesiology and Pain Medicine