Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Francesca R. Farina*, Sean Commins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

Original languageEnglish (US)
Pages (from-to)194-198
Number of pages5
JournalBehavioural Brain Research
Volume307
DOIs
StatePublished - Jul 1 2016

Keywords

  • Glutamate receptors
  • Hippocampus
  • Immediate early genes
  • Prefrontal cortex
  • Spatial memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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