Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Francesca R. Farina; Sean Commins

doi:10.1016/j.bbr.2016.04.002

Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Francesca R. Farina^*, Sean Commins

^*Corresponding author for this work

Medical Social Sciences

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

Original language	English (US)
Pages (from-to)	194-198
Number of pages	5
Journal	Behavioural Brain Research
Volume	307
DOIs	https://doi.org/10.1016/j.bbr.2016.04.002
State	Published - Jul 1 2016

Keywords

Glutamate receptors
Hippocampus
Immediate early genes
Prefrontal cortex
Spatial memory

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2016.04.002

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title = "Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism",

abstract = "The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.",

keywords = "Glutamate receptors, Hippocampus, Immediate early genes, Prefrontal cortex, Spatial memory",

author = "Farina, {Francesca R.} and Sean Commins",

note = "Funding Information: This work was funded by the Maynooth University Doctoral Teaching scholarship held by F.R.F. Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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T1 - Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

AU - Farina, Francesca R.

AU - Commins, Sean

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Y1 - 2016/7/1

N2 - The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

AB - The objective of this study was to examine the effects of NMDAR and AMPAR antagonism on the expression of Zif268 and c-Fos in the hippocampus and medial prefrontal cortex during spatial memory encoding in rats trained in the Morris water maze. NMDAR inhibition impaired navigation and significantly attenuated expression of Zif268, but not c-Fos, in area CA1. AMPAR channel blockade had little effect on learning or IEG expression. Overall, Zif268 and c-Fos displayed markedly different patterns of hippocampal and prefrontal expression, with Zif268 being more closely linked to spatial learning.

KW - Glutamate receptors

KW - Hippocampus

KW - Immediate early genes

KW - Prefrontal cortex

KW - Spatial memory

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JO - Behavioural Brain Research

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ER -

Differential expression of immediate early genes Zif268 and c-Fos in the hippocampus and prefrontal cortex following spatial learning and glutamate receptor antagonism

Abstract

Keywords

ASJC Scopus subject areas

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