Abstract
Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 206-216 |
| Number of pages | 11 |
| Journal | Cellular and Molecular Biology Letters |
| Volume | 17 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2012 |
Funding
Foundation of China Research Grants No. 30672753 (Liu) and China 973 grant of 2012CB822100 (Yan). This work was also supported by Grant # 204139 from the American Cancer Society, Illinois Division, Inc, the Dermatology Foundation, and the Astellas Pharma US Research Endowment (Wang). We thank Dr. Robert Lavker and Dr. David L.K. Chen for their careful review of this manuscript. Acknowledgements. This work was supported by National Natural Science
Keywords
- A431 cells
- FUT4 promoter
- Fucosyltransferase
- Methylation
- SCC12 cells
ASJC Scopus subject areas
- Molecular Biology
- Biochemistry
- Cell Biology
