Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation

Hongyan Li, Shaoming Tong, Jiwei Liu, Li Han, Xuesong Yang, Hesheng Hou, Qiu Yan, Xiao Qi Wang*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Enhanced fucosyltransferase IV (FUT4) expression correlates with increased tumor malignancy in many carcinomas. However, little is known about the regulation of FUT4 expression, and whether FUT4 expression is influenced by the methylation status of the FUT4 promoter is unclear. In this study, we demonstrated that FUT4 expression is negatively correlated with the methylation degree of a CpG island in the FUT4 promoter, suggesting that the methylation status of FUT4 promoter regulates the expression of FUT4. The results indicate that manipulating the methylation status of the FUT4 promoter to regulate FUT4 expression may be a novel approach in the treatment of malignant tumors.

Original languageEnglish (US)
Pages (from-to)206-216
Number of pages11
JournalCellular and Molecular Biology Letters
Volume17
Issue number2
DOIs
StatePublished - 2012

Keywords

  • A431 cells
  • FUT4 promoter
  • Fucosyltransferase
  • Methylation
  • SCC12 cells

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'Differential fucosyltransferase IV expression in squamous carcinoma cells is regulated by promoter methylation'. Together they form a unique fingerprint.

Cite this