Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali

Amadou Kone*, Bassirou Diarra, Keira Cohen, Seydou Diabate, Bourahima Kone, Mahamane T. Diakite, Hawa Diarra, Moumine Sanogo, Antieme C.G. Togo, Yeya dit Sadio Sarro, Bocar Baya, Nadie Coulibaly, Ousmane Kodio, Chad J Achenbach, Robert Leo Murphy, Jane Louise Holl, Sophia Siddiqui, Seydou Doumbia, William R. Bishai, Souleymane Diallo & 1 others Mamoudou Maiga

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC), however, the distribution and frequency of MTBC lineages and sublineages vary in different parts of the globe. Mycobacterium africanum, a member of MTBC is responsible for a large percentage of TB cases in West Africa, however, it is rarely identified outside of this part of the World. Whether or not differential HLA polymorphism (an important host factor) is contributing to the geographic restriction of M. africanum to West Africa is unknown. Here, we conducted a cohort study in Mali of newly diagnosed individuals with active pulmonary TB and normal healthy controls. The MTBC isolates were spoligotyped to determine the TB study groups (M. tuberculosis sensu stricto LAM10 and M. africanum), and HLA typing was performed on peripheral blood. Unlike previous reports on other populations, we found that HLA class-I alleles were significantly associated with active TB disease in this population. HLA-B alleles (B*07:02, B*08:01, B*14:02, B*15:03, B*15:10, B*18:01, B*42:01, B*42:02, B*51:01 and B*81:01) were significantly associated with M. africanum (40%-45%) and M. tuberculosis (75%) compared with healthy controls. Many HLA-A alleles (A*02:05, A*34:02, A*66:01 and A*68:02) were also associated with both TB groups (65%-70%). However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups. The differential HLA distribution observed in this study might be at least partially responsible for the geographical restriction of M. africanum infections to West Africa.

Original languageEnglish (US)
Pages (from-to)24-31
Number of pages8
JournalHLA
Volume93
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Mali
Mycobacterium
Mycobacterium tuberculosis
Gene Frequency
Tuberculosis
Western Africa
Alleles
Histocompatibility Testing
HLA-A Antigens
HLA-B Antigens
HLA-DR Antigens
Pulmonary Tuberculosis
Population
Cohort Studies
Infection

Keywords

  • HLA
  • M. africanum
  • Mali
  • West Africa
  • tuberculosis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Genetics

Cite this

Kone, Amadou ; Diarra, Bassirou ; Cohen, Keira ; Diabate, Seydou ; Kone, Bourahima ; Diakite, Mahamane T. ; Diarra, Hawa ; Sanogo, Moumine ; Togo, Antieme C.G. ; Sarro, Yeya dit Sadio ; Baya, Bocar ; Coulibaly, Nadie ; Kodio, Ousmane ; Achenbach, Chad J ; Murphy, Robert Leo ; Holl, Jane Louise ; Siddiqui, Sophia ; Doumbia, Seydou ; Bishai, William R. ; Diallo, Souleymane ; Maiga, Mamoudou. / Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali. In: HLA. 2019 ; Vol. 93, No. 1. pp. 24-31.
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abstract = "Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC), however, the distribution and frequency of MTBC lineages and sublineages vary in different parts of the globe. Mycobacterium africanum, a member of MTBC is responsible for a large percentage of TB cases in West Africa, however, it is rarely identified outside of this part of the World. Whether or not differential HLA polymorphism (an important host factor) is contributing to the geographic restriction of M. africanum to West Africa is unknown. Here, we conducted a cohort study in Mali of newly diagnosed individuals with active pulmonary TB and normal healthy controls. The MTBC isolates were spoligotyped to determine the TB study groups (M. tuberculosis sensu stricto LAM10 and M. africanum), and HLA typing was performed on peripheral blood. Unlike previous reports on other populations, we found that HLA class-I alleles were significantly associated with active TB disease in this population. HLA-B alleles (B*07:02, B*08:01, B*14:02, B*15:03, B*15:10, B*18:01, B*42:01, B*42:02, B*51:01 and B*81:01) were significantly associated with M. africanum (40{\%}-45{\%}) and M. tuberculosis (75{\%}) compared with healthy controls. Many HLA-A alleles (A*02:05, A*34:02, A*66:01 and A*68:02) were also associated with both TB groups (65{\%}-70{\%}). However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups. The differential HLA distribution observed in this study might be at least partially responsible for the geographical restriction of M. africanum infections to West Africa.",
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author = "Amadou Kone and Bassirou Diarra and Keira Cohen and Seydou Diabate and Bourahima Kone and Diakite, {Mahamane T.} and Hawa Diarra and Moumine Sanogo and Togo, {Antieme C.G.} and Sarro, {Yeya dit Sadio} and Bocar Baya and Nadie Coulibaly and Ousmane Kodio and Achenbach, {Chad J} and Murphy, {Robert Leo} and Holl, {Jane Louise} and Sophia Siddiqui and Seydou Doumbia and Bishai, {William R.} and Souleymane Diallo and Mamoudou Maiga",
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Kone, A, Diarra, B, Cohen, K, Diabate, S, Kone, B, Diakite, MT, Diarra, H, Sanogo, M, Togo, ACG, Sarro, YDS, Baya, B, Coulibaly, N, Kodio, O, Achenbach, CJ, Murphy, RL, Holl, JL, Siddiqui, S, Doumbia, S, Bishai, WR, Diallo, S & Maiga, M 2019, 'Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali', HLA, vol. 93, no. 1, pp. 24-31. https://doi.org/10.1111/tan.13448

Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali. / Kone, Amadou; Diarra, Bassirou; Cohen, Keira; Diabate, Seydou; Kone, Bourahima; Diakite, Mahamane T.; Diarra, Hawa; Sanogo, Moumine; Togo, Antieme C.G.; Sarro, Yeya dit Sadio; Baya, Bocar; Coulibaly, Nadie; Kodio, Ousmane; Achenbach, Chad J; Murphy, Robert Leo; Holl, Jane Louise; Siddiqui, Sophia; Doumbia, Seydou; Bishai, William R.; Diallo, Souleymane; Maiga, Mamoudou.

In: HLA, Vol. 93, No. 1, 01.01.2019, p. 24-31.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali

AU - Kone, Amadou

AU - Diarra, Bassirou

AU - Cohen, Keira

AU - Diabate, Seydou

AU - Kone, Bourahima

AU - Diakite, Mahamane T.

AU - Diarra, Hawa

AU - Sanogo, Moumine

AU - Togo, Antieme C.G.

AU - Sarro, Yeya dit Sadio

AU - Baya, Bocar

AU - Coulibaly, Nadie

AU - Kodio, Ousmane

AU - Achenbach, Chad J

AU - Murphy, Robert Leo

AU - Holl, Jane Louise

AU - Siddiqui, Sophia

AU - Doumbia, Seydou

AU - Bishai, William R.

AU - Diallo, Souleymane

AU - Maiga, Mamoudou

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC), however, the distribution and frequency of MTBC lineages and sublineages vary in different parts of the globe. Mycobacterium africanum, a member of MTBC is responsible for a large percentage of TB cases in West Africa, however, it is rarely identified outside of this part of the World. Whether or not differential HLA polymorphism (an important host factor) is contributing to the geographic restriction of M. africanum to West Africa is unknown. Here, we conducted a cohort study in Mali of newly diagnosed individuals with active pulmonary TB and normal healthy controls. The MTBC isolates were spoligotyped to determine the TB study groups (M. tuberculosis sensu stricto LAM10 and M. africanum), and HLA typing was performed on peripheral blood. Unlike previous reports on other populations, we found that HLA class-I alleles were significantly associated with active TB disease in this population. HLA-B alleles (B*07:02, B*08:01, B*14:02, B*15:03, B*15:10, B*18:01, B*42:01, B*42:02, B*51:01 and B*81:01) were significantly associated with M. africanum (40%-45%) and M. tuberculosis (75%) compared with healthy controls. Many HLA-A alleles (A*02:05, A*34:02, A*66:01 and A*68:02) were also associated with both TB groups (65%-70%). However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups. The differential HLA distribution observed in this study might be at least partially responsible for the geographical restriction of M. africanum infections to West Africa.

AB - Tuberculosis (TB) is caused by Mycobacterium tuberculosis complex (MTBC), however, the distribution and frequency of MTBC lineages and sublineages vary in different parts of the globe. Mycobacterium africanum, a member of MTBC is responsible for a large percentage of TB cases in West Africa, however, it is rarely identified outside of this part of the World. Whether or not differential HLA polymorphism (an important host factor) is contributing to the geographic restriction of M. africanum to West Africa is unknown. Here, we conducted a cohort study in Mali of newly diagnosed individuals with active pulmonary TB and normal healthy controls. The MTBC isolates were spoligotyped to determine the TB study groups (M. tuberculosis sensu stricto LAM10 and M. africanum), and HLA typing was performed on peripheral blood. Unlike previous reports on other populations, we found that HLA class-I alleles were significantly associated with active TB disease in this population. HLA-B alleles (B*07:02, B*08:01, B*14:02, B*15:03, B*15:10, B*18:01, B*42:01, B*42:02, B*51:01 and B*81:01) were significantly associated with M. africanum (40%-45%) and M. tuberculosis (75%) compared with healthy controls. Many HLA-A alleles (A*02:05, A*34:02, A*66:01 and A*68:02) were also associated with both TB groups (65%-70%). However, many class II HLA-DR variants were found to be associated with M. tuberculosis but not M. africanum with the exception of the DRB1*03:01, which was associated with both groups. The differential HLA distribution observed in this study might be at least partially responsible for the geographical restriction of M. africanum infections to West Africa.

KW - HLA

KW - M. africanum

KW - Mali

KW - West Africa

KW - tuberculosis

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Kone A, Diarra B, Cohen K, Diabate S, Kone B, Diakite MT et al. Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali. HLA. 2019 Jan 1;93(1):24-31. https://doi.org/10.1111/tan.13448