TY - JOUR
T1 - Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels
AU - Brueggemann, Lioubov I.
AU - Mackie, Alexander R.
AU - Cribbs, Leanne L.
AU - Freda, Jessica
AU - Tripathi, Abhishek
AU - Majetschak, Matthias
AU - Byron, Kenneth L.
PY - 2014/1/24
Y1 - 2014/1/24
N2 - Background: Kv7 potassium channels are regulated by protein kinase C (PKC) and may assemble as Kv7.4/Kv7.5-heteromers. Results: Kv7.4/Kv7.5-heteromers are endogenously expressed in artery myocytes; both subunits are differentially regulated by PKC. Conclusion: Regulation of Kv7 channels by PKC depends on its subunit composition. Significance: Insights into the mechanisms controlling Kv7 currents are important to understand how membrane potential is regulated.
AB - Background: Kv7 potassium channels are regulated by protein kinase C (PKC) and may assemble as Kv7.4/Kv7.5-heteromers. Results: Kv7.4/Kv7.5-heteromers are endogenously expressed in artery myocytes; both subunits are differentially regulated by PKC. Conclusion: Regulation of Kv7 channels by PKC depends on its subunit composition. Significance: Insights into the mechanisms controlling Kv7 currents are important to understand how membrane potential is regulated.
UR - http://www.scopus.com/inward/record.url?scp=84893141143&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893141143&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.527820
DO - 10.1074/jbc.M113.527820
M3 - Article
C2 - 24297175
AN - SCOPUS:84893141143
SN - 0021-9258
VL - 289
SP - 2099
EP - 2111
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 4
ER -