Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels

Lioubov I. Brueggemann, Alexander R. Mackie, Leanne L. Cribbs, Jessica Freda, Abhishek Tripathi, Matthias Majetschak, Kenneth L. Byron*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Background: Kv7 potassium channels are regulated by protein kinase C (PKC) and may assemble as Kv7.4/Kv7.5-heteromers. Results: Kv7.4/Kv7.5-heteromers are endogenously expressed in artery myocytes; both subunits are differentially regulated by PKC. Conclusion: Regulation of Kv7 channels by PKC depends on its subunit composition. Significance: Insights into the mechanisms controlling Kv7 currents are important to understand how membrane potential is regulated.

Original languageEnglish (US)
Pages (from-to)2099-2111
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number4
DOIs
StatePublished - Jan 24 2014

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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