Differentiated short latency response increases after conditioning in inferior colliculus neurons of alert rat

John F. Disterhoft*, Duncan K. Stuart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The responses of 35 inferior colliculus multiple units (MUs) to tone onset were measured in 10 freely moving rats before and after differential behavioral conditioning. MU response changes were found in the 16.8 msec after tone onset (includes 2 msec air travel time) after learning. Responses to CS+ onset increased in 12 of the 35 individual MUs, and in the group of MUs as a whole, after conditioning. The CS+CS- difference increased in 17 of the 35 individual MUs, and in the group of MUs, after conditioning. The response differentiation was significant in the 3.6-6.4 msec interval after the tone reached the animal's ears, the time at which neuronal responses were first evident. Since the inferior colliculus increases were differentiated between CS+ and CS-, they could not be explained by sensitization caused by changed middle ear contractions or by alterations in orientation to the speakers.

Original languageEnglish (US)
Pages (from-to)315-333
Number of pages19
JournalBrain research
Volume130
Issue number2
DOIs
StatePublished - Jul 15 1977

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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