Differentiation between adrenal adenomas and nonadenomas using dynamic contrast-enhanced computed tomography

Xifu Wang, Kangan Li, Haoran Sun, Jinglong Zhao, Linfeng Zheng, Zhuoli Zhang, Renju Bai*, Guixiang Zhang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

This study was performed to evaluate the findings including the time density curve (TD curve), the relative percentage of enhancement washout (Washr) and the absolute percentage of enhancement washout (Washa) at dynamic contrast-enhanced computed tomography (DCE-CT) in 70 patients with 79 adrenal masses (including 44 adenomas and 35 nonadenomas) confirmed histopathologically and/or clinically. The results demonstrated that the TD curves of adrenal masses were classified into 5 types, and the type distribution of the TD curves was significantly different between adenomas and nonadenomas. Types A and C were character­istic of adenomas, whereas types B, D and E were features of nonadenomas. The sensitivity, specificity and accuracy for the diagnosis of adenoma based on the TD curves were 93%, 80% and 87%, respectively. Furthermore, when myelolipomas were excluded, the specificity and accuracy for adenoma were 90% and 92%, respectively. The Washr and the Washa values for the adenomas were higher than those for the nonadenomas. The diagnostic efficiency for adenoma was highest at 7-min delay time at DCE-CT; Washr was more efficient than Washa. Washr ≥ 34% and Washa ≥ 43% were both suggestive of adenomas and, on the contrary, suspi­cious of nonadenomas. The sensitivity, specificity and accuracy for the diagnosis of adenoma were 84%, 77% and 81%, respectively. When myelolipomas were precluded, the diagnostic specificity and accuracy were 87% and 85%, respectively. Therefore, DCE-CT aids in character­ization of adrenal tumors, especially for lipid-poor adenomas which can be correctly categorized on the basis of TD curve combined with the percentage of enhancement washout.

Original languageEnglish (US)
Pages (from-to)6809-6817
Number of pages9
JournalOncoTargets and Therapy
Volume9
DOIs
StatePublished - Nov 3 2016

Keywords

  • Adrenal adenomas
  • Adrenal nonadenomas
  • Dynamic contrast-enhanced CT
  • Enhancement pattern

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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