Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking

Gwendalyn J. Randolph*, Sylvie Beaulieu, Serge Lebecque, Ralph M. Steinman, William A. Muller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Essential to the dendritic cell system of antigen-presenting cells are the veiled dendritic cells that traverse afferent lymph to enter lymph nodes, where they initiate immune responses. The origin of veiled cells, which were discovered 20 years ago, is unclear. Monocytes cultured with endothelium differentiated into dendritic cells within 2 days, particularly after phagocytosing particles in suben-dothelial collagen. These nascent dendritic cells migrated across the endothelium i n the a blumenal-to-lumenal direction, as would occu r during entry i nto lymphatics. Monocytes that remained in the subendothelial matrix became macrophages. Therefore, monocytes have two potential fates associated with distinct patterns of migration.

Original languageEnglish (US)
Pages (from-to)4191-4194
Number of pages4
JournalJournal of Immunology
Volume198
Issue number11
DOIs
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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