Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones

Padmini Salgame*, John S. Abrams, Caol Clayberger, Harris Goldstein, Jacinto Convit, Robert L. Modlin, Barry R. Bloom

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

Functional subsets of human T cells were delineated by analyzing patterns of lymphokines produced by clones from individuals with leprosy and by T cell clones of known function. CD4 clones from individuals with strong cell-mediated immunity produced predominantly interferon-γ, whereas those clones that enhanced antibody formation produced interleukin-4. CD8 cytotoxic T cells secreted interferon-γ. Interleukin-4 was produced by CD8 T suppressor clones from immunologically unresponsive individuals with leprosy and was found to be necessary for suppression in vitro. Both the classic reciprocal relation between antibody formation and cell-mediated immunity and resistance or susceptibility to certain infections may be explained by T cell subsets differing in patterns of lymphokine production.

Original languageEnglish (US)
Pages (from-to)279-282
Number of pages4
JournalScience
Volume254
Issue number5029
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • General

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    Salgame, P., Abrams, J. S., Clayberger, C., Goldstein, H., Convit, J., Modlin, R. L., & Bloom, B. R. (1991). Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science, 254(5029), 279-282. https://doi.org/10.1126/science.1681588