Abstract
A model sample consisting of two different hydroxyapatite (hAp) powders was used as a bone phantom to investigate the extent to which X-ray diffraction tomography could map differences in hAp lattice constants and crystallite size. The diffraction data were collected at beamline 1-ID, the Advanced Photon Source, using monochromatic 65 keV X-radiation, a 25 x 25 μm pinhole beam and translation/rotation data collection. The diffraction pattern was reconstructed for each volume element (voxel) in the sample, and Rietveld refinement was used to determine the hAp lattice constants. The crystallite size for each voxel was also determined from the 00.2 hAp diffraction peak width. The results clearly show that differences between hAp powders could be measured with diffraction tomography.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 103-109 |
| Number of pages | 7 |
| Journal | Journal of Applied Crystallography |
| Volume | 49 |
| DOIs | |
| State | Published - Feb 2016 |
Funding
The authors are grateful to various funding agencies for supporting this research: SRS acknowledges support from NIDCR grant DE001374; SF, HL and HB thank the Human Frontiers Science Program (HFSP), DANSCATT, the Danish Council for Independent Research – Natural Sciences, and the Graduate School of Science and Technology (GSST) of Aarhus University. Use of the Advanced Photon Source is supported by the US Department of Energy, Office of Science, Office of Basic Energy Sciences, under contract No. DEAC02- 06CH11357.
Keywords
- Rietveld refinement
- X-ray diffraction tomography
- bone
- hydroxyapatite
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology