Diffraction tomography and Rietveld refinement of a hydroxyapatite bone phantom

S. Frølich, H. Leemreize, A. Jakus, X. Xiao, R. Shah, H. Birkedal, J. D. Almer, S. R. Stock*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

A model sample consisting of two different hydroxyapatite (hAp) powders was used as a bone phantom to investigate the extent to which X-ray diffraction tomography could map differences in hAp lattice constants and crystallite size. The diffraction data were collected at beamline 1-ID, the Advanced Photon Source, using monochromatic 65 keV X-radiation, a 25 x 25 μm pinhole beam and translation/rotation data collection. The diffraction pattern was reconstructed for each volume element (voxel) in the sample, and Rietveld refinement was used to determine the hAp lattice constants. The crystallite size for each voxel was also determined from the 00.2 hAp diffraction peak width. The results clearly show that differences between hAp powders could be measured with diffraction tomography.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalJournal of Applied Crystallography
Volume49
DOIs
StatePublished - Feb 2016

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Keywords

  • Rietveld refinement
  • X-ray diffraction tomography
  • bone
  • hydroxyapatite

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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