Diffusion-compensated tofts model suggests contrast leakage through aneurysm wall

Charles G. Cantrell, Parmede Vakil, Yong Jeong, Sameer A. Ansari, Timothy J. Carroll*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose: The purpose of this study was to investigate the diffusional transport of contrast agent and its effects on kinetic modeling of dynamic contrast enhanced (DCE) images. Methods: We performed simulations of our diffusion-compensated model and compared these results to human intracranial aneurysms (IAs). We derive an easy-to-use parameterization of diffusional effects that can provide an accurate estimate of diffusion corrected contrast agent leakage rates (ktrans). Finally, we performed re-ansalysis of an existing data set to determine whether diffusion-corrected kinetic parameters improve the identification of high-risk IAs, thereby providing a new MRI-based imaging metric of IA stability based on wall integrity. Results: Probability distributions of simulated versus measured data show contrast leakage away from the aneurysm wall. Parameterization of diffusional effects on ktrans showed high correlation with long-chain methods in both surrounding tissue and near the aneurysm wall (r2 = 0.91 and r2 = 0.90, respectively). Finally, size, ktrans, and (ktrans-ktrans DC) showed significant univariate relationships with rupture risk (P < 0.05). Conclusions: We report the first evidence of diffusion-compensated permeability modeling in intracranial aneurysms and propose a parameterization of diffusional effects on ktrans. Furthermore, a comparison of measured versus simulated data suggests that contrast leakage occurs across the aneurysm wall. Magn Reson Med 78:2388–2398, 2017.

Original languageEnglish (US)
Pages (from-to)2388-2398
Number of pages11
JournalMagnetic resonance in medicine
Issue number6
StatePublished - Dec 2017


  • Tofts model
  • aneurysm
  • contrast leakage
  • rupture risk

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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