Abstract
BACKGROUND AND PURPOSE: The effect of white matter hyperintensities as measured by FLAIR MR imaging on functional impairment and recovery after ischemic stroke has been investigated thoroughly. However, there has been growing interest in investigating normal-appearing white matter microstructural integrity following ischemic stroke onset with techniques such as DTI. MATERIALS AND METHODS: Fifty-two patients with acute ischemic stroke and 36 without stroke were evaluated with a DTI and FLAIR imaging protocol and clinically assessed for the severity of motor impairment using the Motricity Index within 72 hours of suspected symptom onset. RESULTS: There were widespread decreases in fractional anisotropy and increases in mean diffusivity and radial diffusivity for the acute stroke group compared with the nonstroke group. There was a significant positive association between fractional anisotropy and motor function and a significant negative association between mean diffusivity/radial diffusivity and motor function. The normal-appearing white matter ROIs that were most sensitive to the Motricity Index were the anterior/posterior limb of the internal capsule in the infarcted hemisphere and the splenium of the corpus callosum, external capsule, posterior limb/retrolenticular part of the internal capsule, superior longitudinal fasciculus, and cingulum (hippocampus) of the intrahemisphere/contralateral hemisphere. CONCLUSIONS: The microstructural integrity of normal-appearing white matter is a significant parameter to identify neural differences not only between those individuals with and without acute ischemic stroke but also correlated with the severity of acute motor impairment.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 71-78 |
| Number of pages | 8 |
| Journal | American Journal of Neuroradiology |
| Volume | 41 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2020 |
Funding
Disclosures: Carson Ingo—RELATED: Grant: The data collection of this study was funded through the Eleanor Wood Prince Grants Initiative of the Woman’s Board of Northwestern University and the Davee Foundation.* Chen Lin— RELATED: Grant: Woman’s Board of Northwestern Memorial Hospital, Comments: covered imaging scans.* Yurany A. Arevalo—RELATED: Grant: the Eleanor Wood Prince Grants Initiative of the Woman’s Board of Northwestern University and the Davee Foundation.* Shyam Prabhakaran—RELATED: Grant: Women’s Board Foundation Grant*; UNRELATED: Grants/Grants Pending: National Institutes of Health/National Institute of Neurological Disorders and Stroke, Agency for Healthcare Research and Quality*; Royalties: UpToDate.* *Money paid to institution. Received July 30, 2019; accepted after revision October 30. From the Departments of Neurology (C.I., Y.A.A.), Physical Therapy and Human Movement Sciences (C.I.), and Radiology (J.H.), Northwestern University, Chicago, Illinois; Department of Neurology (C.L.), University of Alabama at Birmingham, Birmingham, Alabama; and Department of Neurology (S.P.), University of Chicago Medical Center, Chicago, Illinois. This study was funded through the Eleanor Wood Prince Grants Initiative of the Woman’s Board of Northwestern University and the Davee Foundation. Please address correspondence to Carson Ingo, PhD, Northwestern University, 645 N. Michigan Ave, Suite 850, Room 856, Chicago, IL 60611; e-mail: [email protected] http://dx.doi.org/10.3174/ajnr.A6357
ASJC Scopus subject areas
- Clinical Neurology
- Radiology Nuclear Medicine and imaging