TY - JOUR
T1 - Diffusion tensor imaging identifies changes in normal-appearing white matter within the epileptogenic zone in tuberous sclerosis complex
AU - Widjaja, Elysa
AU - Simao, Gustavo
AU - Mahmoodabadi, Sina Zarei
AU - Ochi, Ayako
AU - Snead, O. Carter
AU - Rutka, James
AU - Otsubo, Hiroshi
PY - 2010/5
Y1 - 2010/5
N2 - Purpose: To evaluate diffusion tensor imaging (DTI) indices of (i) cortical tubers and (ii) normal-appearing subcortical white matter adjacent to cortical tubers within the epileptogenic zone and non-epileptogenic zone. Methods: Twelve children with tuberous sclerosis complex underwent MRI, DTI and magnetoencephalography (MEG). Regions of interest (ROIs) were placed within cortical tubers and normal-appearing subcortical white matter adjacent to cortical tubers within MEG identified epileptogenic zone and non-epileptogenic zone. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ{norm of matrix}{norm of matrix}) and radial diffusivity (λ⊥) were calculated. Results: 26 out of 104 cortical tubers were in the epileptogenic zone. FA of cortical tubers in the epileptogenic zone was significantly lower than non-epileptogenic zone (p=0.015). There were no significant differences between MD (p=0.896), λ{norm of matrix}{norm of matrix} (p=0.672) and λ⊥ (p=0.651) of cortical tubers in the epileptogenic and non-epileptogenic zone. In normal-appearing subcortical white matter within the epileptogenic zone, FA was lower (p=0.001) and λ⊥ (p=0.011) was higher than non-epileptogenic zone. There were no significant differences between MD (p=0.110) and λ{norm of matrix}{norm of matrix} (p=0.735) of normal-appearing subcortical white matter within the epileptogenic and non-epileptogenic zone. Conclusion: DTI changes in normal-appearing white matter within the epileptogenic zone could represent abnormal white matter related to MRI-occult dysplastic cortex or ictal/interictal activity.
AB - Purpose: To evaluate diffusion tensor imaging (DTI) indices of (i) cortical tubers and (ii) normal-appearing subcortical white matter adjacent to cortical tubers within the epileptogenic zone and non-epileptogenic zone. Methods: Twelve children with tuberous sclerosis complex underwent MRI, DTI and magnetoencephalography (MEG). Regions of interest (ROIs) were placed within cortical tubers and normal-appearing subcortical white matter adjacent to cortical tubers within MEG identified epileptogenic zone and non-epileptogenic zone. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ{norm of matrix}{norm of matrix}) and radial diffusivity (λ⊥) were calculated. Results: 26 out of 104 cortical tubers were in the epileptogenic zone. FA of cortical tubers in the epileptogenic zone was significantly lower than non-epileptogenic zone (p=0.015). There were no significant differences between MD (p=0.896), λ{norm of matrix}{norm of matrix} (p=0.672) and λ⊥ (p=0.651) of cortical tubers in the epileptogenic and non-epileptogenic zone. In normal-appearing subcortical white matter within the epileptogenic zone, FA was lower (p=0.001) and λ⊥ (p=0.011) was higher than non-epileptogenic zone. There were no significant differences between MD (p=0.110) and λ{norm of matrix}{norm of matrix} (p=0.735) of normal-appearing subcortical white matter within the epileptogenic and non-epileptogenic zone. Conclusion: DTI changes in normal-appearing white matter within the epileptogenic zone could represent abnormal white matter related to MRI-occult dysplastic cortex or ictal/interictal activity.
KW - Diffusion tensor imaging
KW - Magnetoencephalography
KW - Tuberous sclerosis complex
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U2 - 10.1016/j.eplepsyres.2010.01.008
DO - 10.1016/j.eplepsyres.2010.01.008
M3 - Article
C2 - 20129760
AN - SCOPUS:77951298409
SN - 0920-1211
VL - 89
SP - 246
EP - 253
JO - Epilepsy Research
JF - Epilepsy Research
IS - 2-3
ER -