Diffusion tensor imaging of commissural and projection white matter in tuberous sclerosis complex and correlation with tuber load

G. Simao, C. Raybaud, S. Chuang, C. Go, O. C. Snead, Elysa Widjaja*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

BACKGROUND AND PURPOSE: Cortical and white matter changes have been identified outside the MR imaging-visible cortical/subcortical tubers in the tuberous sclerosis complex. The aim of this study was to evaluate DTI changes in the corpus callosum and internal capsules and to correlate the DTI changes with cortical/subcortical tuber load. MATERIALS AND METHODS: Twelve TSC patients and 23 controls underwent MR imaging including DTI. FA, trace, D∥, and D⊥ of genu and splenium of corpus callosum and right and left internal capsules were assessed. The number and volume of cortical/subcortical tubers were correlated with DTI indices of corpus callosum and internal capsules. RESULTS: In the genu and splenium, FA was lower and trace (P < .01) and D⊥ were higher (P < .01), and in the internal capsules, trace was higher (P = .04) in TSC patients compared with controls. The total tuber volume correlated positively with trace of genu (r = 0.77, P < .01) and splenium (r = 0.69, P = .01) and with D⊥ of splenium (r = 0.68, P = .01), and negatively with FA of splenium (r = -0.60, P = .04) of corpus callosum. The left and right hemispheric tuber volume correlated positively with trace of left (r = 0.56, P = .05) and right (r = 0.67, P = .02) internal capsules. CONCLUSIONS: Our findings of reduced FA, elevated trace, and elevated D⊥ in the corpus callosum and internal capsules may be related to abnormalities in myelin. The correlations between tuber volume and DTI indices in corpus callosum and internal capsules suggested that more extensive malformation as demonstrated by larger tuber load was more likely to be associated with more severe DTI changes in the commissural and projection white matter.

Original languageEnglish (US)
Pages (from-to)1273-1277
Number of pages5
JournalAmerican Journal of Neuroradiology
Volume31
Issue number7
DOIs
StatePublished - Aug 2010

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging

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