Diffusion tensor imaging of Parkinson's disease, atypical parkinsonism, and essential tremor

Janey Prodoehl, Hong Li, Peggy J. Planetta, Christopher G. Goetz, Kathleen M. Shannon, Ruth Tangonan, Cynthia L. Comella, Tanya Simuni, Xiaohong Joe Zhou, Sue Leurgans, Daniel M. Corcos, David E. Vaillancourt*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

Diffusion tensor imaging could be useful in characterizing movement disorders because it noninvasively examines multiple brain regions simultaneously. We report a multitarget imaging approach focused on the basal ganglia and cerebellum in Parkinson's disease, parkinsonian variant of multiple system atrophy, progressive supranuclear palsy, and essential tremor and in healthy controls. Seventy-two subjects were studied with a diffusion tensor imaging protocol at 3 Tesla. Receiver operating characteristic analysis was performed to directly compare groups. Sensitivity and specificity values were quantified for control versus movement disorder (92% sensitivity, 88% specificity), control versus parkinsonism (93% sensitivity, 91% specificity), Parkinson's disease versus atypical parkinsonism (90% sensitivity, 100% specificity), Parkinson's disease versus multiple system atrophy (94% sensitivity, 100% specificity), Parkinson's disease versus progressive supranuclear palsy (87% sensitivity, 100% specificity), multiple system atrophy versus progressive supranuclear palsy (90% sensitivity, 100% specificity), and Parkinson's disease versus essential tremor (92% sensitivity, 87% specificity). The brain targets varied for each comparison, but the substantia nigra, putamen, caudate, and middle cerebellar peduncle were the most frequently selected brain regions across classifications. These results indicate that using diffusion tensor imaging of the basal ganglia and cerebellum accurately classifies subjects diagnosed with Parkinson's disease, atypical parkinsonism, and essential tremor and clearly distinguishes them from control subjects.

Original languageEnglish (US)
Pages (from-to)1816-1822
Number of pages7
JournalMovement Disorders
Volume28
Issue number13
DOIs
StatePublished - Nov 2013

Keywords

  • Basal ganglia
  • Cerebellum
  • DTI
  • Essential tremor
  • Parkinsonism

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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