Diffusion-weighted MR imaging for determination of hepatocellular carcinoma response to yttrium-90 radioembolization

Jie Deng, Frank H. Miller, Thomas K. Rhee, Kent T. Sato, Mary F. Mulcahy, Laura M. Kulik, Riad Salem, Reed A. Omary, Andrew C. Larson*

*Corresponding author for this work

Research output: Contribution to journalArticle

78 Scopus citations

Abstract

Early detection of the response of hepatocellular carcinoma (HCC) to yttrium-90 radioembolization therapy may be important to permit repeat radioembolization or alternative treatment options. Water-mobility measurements with use of diffusion-weighted (DW) magnetic resonance (MR) imaging are useful for noninvasive interrogation of microstructural tissue properties. Findings of DW MR imaging may serve as an early biomarker of HCC response. This study tested the hypothesis that DW MR imaging can detect changes in tumor tissue water diffusion in response to Y therapy. In each of six patients with HCC included in the study, tumor water diffusion increased significantly after therapy. DW MR imaging is a promising technique for noninvasive assessment of tumor response to Y radioembolization.

Original languageEnglish (US)
Pages (from-to)1195-1200
Number of pages6
JournalJournal of Vascular and Interventional Radiology
Volume17
Issue number7
DOIs
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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