Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

Su Hu, Chong Sun, Bin Wang, Kang Zhou, Liang Pan, Junjie Shangguan, Jia Yang, Vahid Yaghmai, Matteo Figini, Zhuoli Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Materials and Methods: Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. Results: The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10−3 mm2/s ± 0.15 vs 0.88 × 10−3 mm2/s ± 0.19; P = .042). Conclusions: DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.

Original languageEnglish (US)
Pages (from-to)1863-1869
Number of pages7
JournalJournal of Vascular and Interventional Radiology
Issue number11
StatePublished - Nov 2019

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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