Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

Su Hu; Chong Sun; Bin Wang; Kang Zhou; Liang Pan; Junjie Shangguan; Jia Yang; Vahid Yaghmai; Matteo Figini; Zhuoli Zhang

doi:10.1016/j.jvir.2019.05.030

Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

Su Hu, Chong Sun, Bin Wang, Kang Zhou, Liang Pan, Junjie Shangguan, Jia Yang, Vahid Yaghmai, Matteo Figini, Zhuoli Zhang^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Materials and Methods: Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. Results: The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10⁻³ mm²/s ± 0.15 vs 0.88 × 10⁻³ mm²/s ± 0.19; P = .042). Conclusions: DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.

Original language	English (US)
Pages (from-to)	1863-1869
Number of pages	7
Journal	Journal of Vascular and Interventional Radiology
Volume	30
Issue number	11
DOIs	https://doi.org/10.1016/j.jvir.2019.05.030
State	Published - Nov 2019

Funding

The authors thank Quanhong Ma for assistance with animal studies and acknowledge the helpful advice of Chunhong Hu, Jian Wang, Andrew C. Larson, and Yuri Velichko. This work was supported by National Cancer Institute Grants R01CA209886 and R01CA196967 and Key Research and Development Program of Tianjin Municipal Science and Technology Commission Grant 17YFZCSY00870 .

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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title = "Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model",

abstract = "Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Materials and Methods: Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. Results: The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10−3 mm2/s ± 0.15 vs 0.88 × 10−3 mm2/s ± 0.19; P = .042). Conclusions: DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.",

author = "Su Hu and Chong Sun and Bin Wang and Kang Zhou and Liang Pan and Junjie Shangguan and Jia Yang and Vahid Yaghmai and Matteo Figini and Zhuoli Zhang",

note = "Funding Information: The authors thank Quanhong Ma for assistance with animal studies and acknowledge the helpful advice of Chunhong Hu, Jian Wang, Andrew C. Larson, and Yuri Velichko. This work was supported by National Cancer Institute Grants R01CA209886 and R01CA196967 and Key Research and Development Program of Tianjin Municipal Science and Technology Commission Grant 17YFZCSY00870 . Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = nov,

doi = "10.1016/j.jvir.2019.05.030",

language = "English (US)",

volume = "30",

pages = "1863--1869",

journal = "Journal of Vascular and Interventional Radiology",

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T1 - Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

AU - Hu, Su

AU - Sun, Chong

AU - Wang, Bin

AU - Zhou, Kang

AU - Pan, Liang

AU - Shangguan, Junjie

AU - Yang, Jia

AU - Yaghmai, Vahid

AU - Figini, Matteo

AU - Zhang, Zhuoli

N1 - Funding Information: The authors thank Quanhong Ma for assistance with animal studies and acknowledge the helpful advice of Chunhong Hu, Jian Wang, Andrew C. Larson, and Yuri Velichko. This work was supported by National Cancer Institute Grants R01CA209886 and R01CA196967 and Key Research and Development Program of Tianjin Municipal Science and Technology Commission Grant 17YFZCSY00870 . Publisher Copyright: © 2019

PY - 2019/11

Y1 - 2019/11

N2 - Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Materials and Methods: Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. Results: The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10−3 mm2/s ± 0.15 vs 0.88 × 10−3 mm2/s ± 0.19; P = .042). Conclusions: DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.

AB - Purpose: To evaluate the feasibility of diffusion-weighted imaging (DWI) in magnetic resonance imaging for quantitative measurement of responses following irreversible electroporation (IRE) in a rabbit liver tumor model. Materials and Methods: Twelve rabbits underwent ultrasound-guided VX2 tumor implantation in the left medial and left lateral liver lobes. The tumors in the left medial lobe were treated with IRE, whereas those in the left lateral lobe served as internal controls. DWI was performed before and immediately after IRE. Tumors were then harvested for histopathologic staining. The apparent diffusion coefficient (ADC) and change in ADC (ΔADC) were calculated based on DWI. Tumor apoptosis index (AI) was assessed by terminal deoxynucleotidyl transferase dUTP nick-end labeling. These measurements from DWI and histopathology were compared between untreated and treated tumors. Results: The ADC values, ΔADC, and AI showed statistically significant differences between treated and untreated tumors (P < .05 for all). ADC values were higher in treated tumors than in untreated tumors (1.08 × 10−3 mm2/s ± 0.15 vs 0.88 × 10−3 mm2/s ± 0.19; P = .042). Conclusions: DWI can be used to quantitatively evaluate treatment response in liver tumors immediately after IRE.

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Diffusion-Weighted MR Imaging to Evaluate Immediate Response to Irreversible Electroporation in a Rabbit VX2 Liver Tumor Model

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