TY - JOUR
T1 - Digitoxin Prolongs Survival of Female Rats With Heart Failure Due to Large Myocardial Infarction
AU - Helber, Izo
AU - Dos Santos, Alexandra A.
AU - Antonio, Ednei L.
AU - Flumignan, Ronald L.G.
AU - Bocalini, Danilo S.
AU - Piccolo, Camila
AU - Gheorghiade, Mihai
AU - Tucci, Paulo J.F.
PY - 2009/11
Y1 - 2009/11
N2 - Background: We analyzed whether digitoxin affects the survival of rats with congestive heart failure. Methods and Results: The influence of digitoxin (0.1 mg·100 g·day, orally) on the survival of infarcted female rats (n = 170) randomized as Control Infarcted (CI, n = 85) or Digitoxin (D, n = 85) was evaluated for 280 days. Mean survival was 235 ± 7 days for CI and 255 ± 5 days for D (log-rank test: P = .0602). Digitoxin did not affect survival in rats with congestive heart failure from myocardial infarction <40% of the left ventricle, but did prolong survival in rats with infarction ≥40%. The log-rank test defined higher mortality (P = .0161) in CI >40% (56%) than in D >40% (34%), with a hazard ratio of 2.03. Pulmonary water content and papillary muscle mechanics were analyzed in CI (n = 7) and D (n = 14) survivors. Significant differences were observed regarding pulmonary water content (CI: 82 ± 0.3; D: 80 ± 0.3%; P = .0014), developed tension (CI: 2.7 ± 0.3; D: 3.8 ± 0.3 g/mm2; P = .0286) and +dT/dt (CI: 24 ± 3; D: 39 ± 4 mg mm2·s; P = .0109). Conclusion: In conclusion, long-term digitoxin administration reduced cardiac impairment after myocardium infarction, attenuated myocardial dysfunction, reduced pulmonary congestion, and provided the first evidence regarding the efficiency of digitoxin in prolonging survival in experimental cardiac failure.
AB - Background: We analyzed whether digitoxin affects the survival of rats with congestive heart failure. Methods and Results: The influence of digitoxin (0.1 mg·100 g·day, orally) on the survival of infarcted female rats (n = 170) randomized as Control Infarcted (CI, n = 85) or Digitoxin (D, n = 85) was evaluated for 280 days. Mean survival was 235 ± 7 days for CI and 255 ± 5 days for D (log-rank test: P = .0602). Digitoxin did not affect survival in rats with congestive heart failure from myocardial infarction <40% of the left ventricle, but did prolong survival in rats with infarction ≥40%. The log-rank test defined higher mortality (P = .0161) in CI >40% (56%) than in D >40% (34%), with a hazard ratio of 2.03. Pulmonary water content and papillary muscle mechanics were analyzed in CI (n = 7) and D (n = 14) survivors. Significant differences were observed regarding pulmonary water content (CI: 82 ± 0.3; D: 80 ± 0.3%; P = .0014), developed tension (CI: 2.7 ± 0.3; D: 3.8 ± 0.3 g/mm2; P = .0286) and +dT/dt (CI: 24 ± 3; D: 39 ± 4 mg mm2·s; P = .0109). Conclusion: In conclusion, long-term digitoxin administration reduced cardiac impairment after myocardium infarction, attenuated myocardial dysfunction, reduced pulmonary congestion, and provided the first evidence regarding the efficiency of digitoxin in prolonging survival in experimental cardiac failure.
KW - Psychological
KW - survival
UR - http://www.scopus.com/inward/record.url?scp=70350571759&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70350571759&partnerID=8YFLogxK
U2 - 10.1016/j.cardfail.2009.05.002
DO - 10.1016/j.cardfail.2009.05.002
M3 - Article
C2 - 19879467
AN - SCOPUS:70350571759
SN - 1071-9164
VL - 15
SP - 798
EP - 804
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
IS - 9
ER -