Dihydroergocryptine protects from acute experimental allergic encephalomyelitis in the rat

P. L. Canonico*, M. A. Sortino, A. Favit, G. Aleppo, U. Scapagnini

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The effect of dihydroergocryptine, a natural alkaloid derivative which exhibits D2 dopaminomimetic properties, has been studied in Lewis female rats with experimentally induced allergic encephalomyelitis. A chronic treatment with dihydroergocryptine started two days before immunization, induced a dramatic reduction of prolactin levels accompanied by a marked amelioration of neurological signs. In addition, the proliferative activity of splenic lymphocytes induced by the mitogen Concanavalin-A (Con-A) was reduced in dihydroergocryptine-treated animals. It is suggested that this effect is related to the ability of dihydroergocryptine to lower prolactin concentrations or also, partially, to a neuroprotective action of this drug.

Original languageEnglish (US)
Pages (from-to)183-188
Number of pages6
JournalFunctional Neurology
Volume8
Issue number3
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Canonico, P. L., Sortino, M. A., Favit, A., Aleppo, G., & Scapagnini, U. (1993). Dihydroergocryptine protects from acute experimental allergic encephalomyelitis in the rat. Functional Neurology, 8(3), 183-188.