TY - JOUR
T1 - Dilated intercellular spaces
T2 - Extending the reach of the endoscope
AU - Kahrilas, Peter J
PY - 2005/3/1
Y1 - 2005/3/1
N2 - Two manuscripts in this issue utilize quantitative methods to analyze the association between gastroesophageal reflux disease (GERD) and dilated intercellular spaces (DIS) evident on transmission electron microscopy of the esophageal epithelium. One study of 20 patients found that, irrespective of whether or not a pH study was positive, all GERD patients who had responded to proton pump inhibitors therapy had intercellular space measurements that were at least twice normal. The other study demonstrated that DIS resolved with effective GERD therapy in essentially every instance. Both studies suggest that DIS are an objective structural marker of endoscopy-negative reflux disease.
AB - Two manuscripts in this issue utilize quantitative methods to analyze the association between gastroesophageal reflux disease (GERD) and dilated intercellular spaces (DIS) evident on transmission electron microscopy of the esophageal epithelium. One study of 20 patients found that, irrespective of whether or not a pH study was positive, all GERD patients who had responded to proton pump inhibitors therapy had intercellular space measurements that were at least twice normal. The other study demonstrated that DIS resolved with effective GERD therapy in essentially every instance. Both studies suggest that DIS are an objective structural marker of endoscopy-negative reflux disease.
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U2 - 10.1111/j.1572-0241.2005.41918.x
DO - 10.1111/j.1572-0241.2005.41918.x
M3 - Review article
C2 - 15743350
AN - SCOPUS:16844374443
SN - 0002-9270
VL - 100
SP - 549
EP - 550
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 3
ER -