Dimensions of outcome with clozapine

H. Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

233 Scopus citations


Various outcome measures following clozapine administration to neuroleptic-resistant schizophrenic patients are considered. The importance of a multidimensional perspective is emphasised. There was significant improvement in positive symptoms, some negative symptoms, quality of life, some types of cognitive function (e.g. semantic memory), extrapyramidal function, and tardive dyskinesia. Readmission to hospital, and family burden were markedly reduced, which achieved significant savings in the cost of treatment. Compliance with clozapine and weekly blood testing can be achieved in the majority of treatment-resistant cases. These benefits may occur independently of each other.

Original languageEnglish (US)
Pages (from-to)46-53
Number of pages8
JournalBritish Journal of Psychiatry
Issue numberMAY. SUPPL. 17
StatePublished - 1992

ASJC Scopus subject areas

  • Psychiatry and Mental health


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