TY - JOUR
T1 - Dimensions of outcome with clozapine
AU - Meltzer, H. Y.
PY - 1992
Y1 - 1992
N2 - Various outcome measures following clozapine administration to neuroleptic-resistant schizophrenic patients are considered. The importance of a multidimensional perspective is emphasised. There was significant improvement in positive symptoms, some negative symptoms, quality of life, some types of cognitive function (e.g. semantic memory), extrapyramidal function, and tardive dyskinesia. Readmission to hospital, and family burden were markedly reduced, which achieved significant savings in the cost of treatment. Compliance with clozapine and weekly blood testing can be achieved in the majority of treatment-resistant cases. These benefits may occur independently of each other.
AB - Various outcome measures following clozapine administration to neuroleptic-resistant schizophrenic patients are considered. The importance of a multidimensional perspective is emphasised. There was significant improvement in positive symptoms, some negative symptoms, quality of life, some types of cognitive function (e.g. semantic memory), extrapyramidal function, and tardive dyskinesia. Readmission to hospital, and family burden were markedly reduced, which achieved significant savings in the cost of treatment. Compliance with clozapine and weekly blood testing can be achieved in the majority of treatment-resistant cases. These benefits may occur independently of each other.
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U2 - 10.1192/s000712500029692x
DO - 10.1192/s000712500029692x
M3 - Review article
C2 - 1418889
AN - SCOPUS:0026517979
VL - 160
SP - 46
EP - 53
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
SN - 0007-1250
IS - MAY. SUPPL. 17
ER -