Dinitrochlorobenzene: Inflammatory Response and Delayed Cutaneous Hypersensitivity

Michael W. Johnson; Howard I. Maibach; Sydney E. Salmon; William J. Catalona; Peyton T. Taylor; Paul B. Chretien

doi:10.1056/NEJM197205252862121

Dinitrochlorobenzene: Inflammatory Response and Delayed Cutaneous Hypersensitivity

Michael W. Johnson, Howard I. Maibach, Sydney E. Salmon, William J. Catalona, Peyton T. Taylor, Paul B. Chretien

Urology

Research output: Contribution to journal › Letter › peer-review

2 Scopus citations

Abstract

To the Editor: The authors of the recent article on contact sensitization¹ failed to appreciate the importance of graded assessment of the inflammatory response in subjects studied for delayed cutaneous hypersensitivity (DCH) to dinitro-chlorobenzene (DNCB), perhaps owing to misinterpretation of our findings.² In the study by Catalona et al.¹ 12 patients with cancer did not have DCH to DNCB, but nine of these patients had “irritative reactions” to the sensitizing dose of DNCB. Catalona said that this was inconsistent with our study, which showed an impaired inflammatory response to 10 per cent croton oil in patients with cancer who had.

Original language	English (US)
Pages (from-to)	1162
Number of pages	1
Journal	New England Journal of Medicine
Volume	286
Issue number	21
DOIs	https://doi.org/10.1056/NEJM197205252862121
State	Published - May 25 1972

ASJC Scopus subject areas

General Medicine

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title = "Dinitrochlorobenzene: Inflammatory Response and Delayed Cutaneous Hypersensitivity",

abstract = "To the Editor: The authors of the recent article on contact sensitization1 failed to appreciate the importance of graded assessment of the inflammatory response in subjects studied for delayed cutaneous hypersensitivity (DCH) to dinitro-chlorobenzene (DNCB), perhaps owing to misinterpretation of our findings.2 In the study by Catalona et al.1 12 patients with cancer did not have DCH to DNCB, but nine of these patients had “irritative reactions” to the sensitizing dose of DNCB. Catalona said that this was inconsistent with our study, which showed an impaired inflammatory response to 10 per cent croton oil in patients with cancer who had.",

author = "Johnson, {Michael W.} and Maibach, {Howard I.} and Salmon, {Sydney E.} and Catalona, {William J.} and Taylor, {Peyton T.} and Chretien, {Paul B.}",

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language = "English (US)",

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T1 - Dinitrochlorobenzene

T2 - Inflammatory Response and Delayed Cutaneous Hypersensitivity

AU - Johnson, Michael W.

AU - Maibach, Howard I.

AU - Salmon, Sydney E.

AU - Catalona, William J.

AU - Taylor, Peyton T.

AU - Chretien, Paul B.

PY - 1972/5/25

Y1 - 1972/5/25

N2 - To the Editor: The authors of the recent article on contact sensitization1 failed to appreciate the importance of graded assessment of the inflammatory response in subjects studied for delayed cutaneous hypersensitivity (DCH) to dinitro-chlorobenzene (DNCB), perhaps owing to misinterpretation of our findings.2 In the study by Catalona et al.1 12 patients with cancer did not have DCH to DNCB, but nine of these patients had “irritative reactions” to the sensitizing dose of DNCB. Catalona said that this was inconsistent with our study, which showed an impaired inflammatory response to 10 per cent croton oil in patients with cancer who had.

AB - To the Editor: The authors of the recent article on contact sensitization1 failed to appreciate the importance of graded assessment of the inflammatory response in subjects studied for delayed cutaneous hypersensitivity (DCH) to dinitro-chlorobenzene (DNCB), perhaps owing to misinterpretation of our findings.2 In the study by Catalona et al.1 12 patients with cancer did not have DCH to DNCB, but nine of these patients had “irritative reactions” to the sensitizing dose of DNCB. Catalona said that this was inconsistent with our study, which showed an impaired inflammatory response to 10 per cent croton oil in patients with cancer who had.

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Dinitrochlorobenzene: Inflammatory Response and Delayed Cutaneous Hypersensitivity

Abstract

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