Diphenylhydantoin and wound healing

M. C. Stalnecker, V. L. Lewis, K. Benveniste

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Diphenylhydantoin (DPH) has been reported to increase the tensile strength and healing rate of bone and soft tissue in animals and humans. It has been shown to stimulate proliferation of fibroblasts, increase collagen content in nonwounded rat skin, and affect collagen synthesis and degradation in tissue culture. This project evaluates, by mechanical testing and biochemical analyses, the effect of DPH on cutaneous wounds in rats. Results in rats indicate that, when given in a short perioperative course, DPH may enhance early tensile strength gain. Longer treatment appears to have an adverse effect on wound strength.

Original languageEnglish (US)
Pages (from-to)622-625
Number of pages4
JournalSurgical Forum
VolumeVOL. 34
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Surgery


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