Direct action of estradiol on rat mammary tumors

Chung Lee, R. Oyasu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


To demonstrate a direct effect of estrogen on the growth of 7,12 dimethylbenz[a]anthracene (DMBA) induced rat mammary tumors, the authors studied the in vitro incorporation of 3H leucine by the tumors. Tumor tissue obtained from ovariectomized rats was incubated at 37°C for 2 hr under 95% oxygen and 5% carbon dioxide in a chemically defined medium containing 0.5 μCi/ml 3H leucine. The addition of 0.1 μg/ml 17β estradiol to the incubation medium increased the incorporation of radioactivity into tumor protein by 7%. This increase was statistically significant (P<0.001). It is concluded that estrogen directly stimulates protein synthesis in the mammary tumors.

Original languageEnglish (US)
Pages (from-to)283-284
Number of pages2
JournalJournal of the National Cancer Institute
Issue number1
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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