Direct amination of γ-Halo-β-ketoesters with anilines

Yinan Zhang, Richard B. Silverman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.

Original languageEnglish (US)
Pages (from-to)3462-3467
Number of pages6
JournalJournal of Organic Chemistry
Volume77
Issue number7
DOIs
StatePublished - Apr 6 2012

ASJC Scopus subject areas

  • Organic Chemistry

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