Direct amination of γ-Halo-β-ketoesters with anilines

Yinan Zhang; Richard B. Silverman

doi:10.1021/jo300239e

Direct amination of γ-Halo-β-ketoesters with anilines

Yinan Zhang, Richard B. Silverman^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.

Original language	English (US)
Pages (from-to)	3462-3467
Number of pages	6
Journal	Journal of Organic Chemistry
Volume	77
Issue number	7
DOIs	https://doi.org/10.1021/jo300239e
State	Published - Apr 6 2012

ASJC Scopus subject areas

Organic Chemistry

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10.1021/jo300239e

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title = "Direct amination of γ-Halo-β-ketoesters with anilines",

abstract = "The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.",

author = "Yinan Zhang and Silverman, {Richard B.}",

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AU - Silverman, Richard B.

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AB - The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.

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JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

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Direct amination of γ-Halo-β-ketoesters with anilines

Abstract

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