TY - JOUR
T1 - Direct comparison of two methods to measure T1
T2 - In vitro and in vivo values by echo-planar imaging and by segmented k-space imaging
AU - Haselgrove, John
AU - Hunte, Michael
AU - Hurh, Peter
AU - Steen, R. Grant
N1 - Funding Information:
This work was supported by the National Heart, Lung, and Blood Institute (HL 60022 to R.G.S.), by the National Cancer Institute (CA 23944 in support of M.H.), and by American-Lebanese-Syrian Associated Charities (ALSAC).
PY - 2004/4
Y1 - 2004/4
N2 - We test a hypothesis that proton T1 is accurately measured independent of the physics inherent to the method. We used two well-validated but quite different imaging methods to measure T1 in phantoms and in humans; an echo-planar imaging T-one measurement (EPITOME) method, and a segmented k-space acquisition precise and accurate inversion recovery (TurboPAIR) method. Agreement between the methods was generally excellent; the square of the correlation coefficient (r2) in phantoms was 0.9996. The r2 in brain tissue of volunteers was 0.79 overall, and 0.85 if cortical gray matter and corpus callosum were excluded. Nevertheless, small but significant differences were observed between methods in vivo and T1 measurements were sensitive to tissue type, although measurements could be made comparable. The major difference between the methods is that EPITOME takes 97 s to image 15 slices at low resolution, while TurboPAIR takes 240 s to image one slice at high resolution.
AB - We test a hypothesis that proton T1 is accurately measured independent of the physics inherent to the method. We used two well-validated but quite different imaging methods to measure T1 in phantoms and in humans; an echo-planar imaging T-one measurement (EPITOME) method, and a segmented k-space acquisition precise and accurate inversion recovery (TurboPAIR) method. Agreement between the methods was generally excellent; the square of the correlation coefficient (r2) in phantoms was 0.9996. The r2 in brain tissue of volunteers was 0.79 overall, and 0.85 if cortical gray matter and corpus callosum were excluded. Nevertheless, small but significant differences were observed between methods in vivo and T1 measurements were sensitive to tissue type, although measurements could be made comparable. The major difference between the methods is that EPITOME takes 97 s to image 15 slices at low resolution, while TurboPAIR takes 240 s to image one slice at high resolution.
UR - http://www.scopus.com/inward/record.url?scp=1942420787&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1942420787&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2004.01.021
DO - 10.1016/j.mri.2004.01.021
M3 - Article
C2 - 15062924
AN - SCOPUS:1942420787
VL - 22
SP - 291
EP - 298
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
IS - 3
ER -