Direct comparison of two methods to measure T1: In vitro and in vivo values by echo-planar imaging and by segmented k-space imaging

John Haselgrove, Michael Hunte, Peter Hurh, R. Grant Steen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We test a hypothesis that proton T1 is accurately measured independent of the physics inherent to the method. We used two well-validated but quite different imaging methods to measure T1 in phantoms and in humans; an echo-planar imaging T-one measurement (EPITOME) method, and a segmented k-space acquisition precise and accurate inversion recovery (TurboPAIR) method. Agreement between the methods was generally excellent; the square of the correlation coefficient (r2) in phantoms was 0.9996. The r2 in brain tissue of volunteers was 0.79 overall, and 0.85 if cortical gray matter and corpus callosum were excluded. Nevertheless, small but significant differences were observed between methods in vivo and T1 measurements were sensitive to tissue type, although measurements could be made comparable. The major difference between the methods is that EPITOME takes 97 s to image 15 slices at low resolution, while TurboPAIR takes 240 s to image one slice at high resolution.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalMagnetic Resonance Imaging
Volume22
Issue number3
DOIs
StatePublished - Apr 2004

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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