Direct, electronic microRNA detection for the rapid determination of differential expression profiles

Hong Yang; Angela Hui; George Pampalakis; Leyla Soleymani; Fei Fei Liu; Edward H. Sargent; Shana O. Kelley

doi:10.1002/anie.200902577

Direct, electronic microRNA detection for the rapid determination of differential expression profiles

Hong Yang, Angela Hui, George Pampalakis, Leyla Soleymani, Fei Fei Liu, Edward H. Sargent, Shana O. Kelley

Chemistry

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

In the time it takes for lunch: An electronic chip featuring nanostructured microelectrodes (NMEs) enables the analysis of microRNA expression profiles in just 30 min in small RNA samples without enzymatic amplification or sequence labeling. The multiplexed chip detects the hybridization of microRNA targets to NME surfaces and provides large electrocatalytic gain through the use of an ultrasensitive redox reporter system (see picture).

Original language	English (US)
Pages (from-to)	8461-8464
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	45
DOIs	https://doi.org/10.1002/anie.200902577
State	Published - Oct 26 2009

Keywords

Biosensors
Microchips
Microelectrodes
Microrna
Nucleic acids

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.200902577

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AU - Hui, Angela

AU - Pampalakis, George

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AU - Liu, Fei Fei

AU - Sargent, Edward H.

AU - Kelley, Shana O.

PY - 2009/10/26

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KW - Biosensors

KW - Microchips

KW - Microelectrodes

KW - Microrna

KW - Nucleic acids

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Direct, electronic microRNA detection for the rapid determination of differential expression profiles

Abstract

Keywords

ASJC Scopus subject areas

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