Direct, electronic microRNA detection for the rapid determination of differential expression profiles

Hong Yang, Angela Hui, George Pampalakis, Leyla Soleymani, Fei Fei Liu, Edward H. Sargent, Shana O. Kelley

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

In the time it takes for lunch: An electronic chip featuring nanostructured microelectrodes (NMEs) enables the analysis of microRNA expression profiles in just 30 min in small RNA samples without enzymatic amplification or sequence labeling. The multiplexed chip detects the hybridization of microRNA targets to NME surfaces and provides large electrocatalytic gain through the use of an ultrasensitive redox reporter system (see picture).

Original languageEnglish (US)
Pages (from-to)8461-8464
Number of pages4
JournalAngewandte Chemie - International Edition
Volume48
Issue number45
DOIs
StatePublished - Oct 26 2009
Externally publishedYes

Keywords

  • Biosensors
  • Microchips
  • Microelectrodes
  • Microrna
  • Nucleic acids

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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