Direct measurement of pulmonary microvascular distensibility

S. C. Hillier*, P. S. Godbey, C. C. Hanger, J. A. Graham, R. G. Presson, O. Okada, J. H. Linehan, C. A. Dawson, W. W. Wagner

*Corresponding author for this work

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Pulmonary vascular distensibility has an important influence on pulmonary hemodynamics. Although many measurements of distensibility have been made on large pulmonary vessels, there is less information on microvascular distensibility. We have measured the distensibility of the smallest (<70- μm-diam) precapillary arterioles and postcapillary venules. Isolated dog lobes, at 2.5 cmH2O transpulmonary pressure, were perfused at low flows, which caused the arteriovenous pressure gradient to be very small and thereby permitted accurate estimation of microvascular pressure. As microvascular pressure was systematically varied between 0 and 30 mmHg, subpleural microvascular diameters were determined from computer-enhanced images obtained by videomicroscopy. Arteriolar and venular distensibilities were not different from each other. The microvascular pressure-diameter relationship was alinear with distensibility coefficients of 1-3% mmHg-1, values that are of the same order of magnitude as previously measured distensibilities of 100- to 1,000-μm-diam canine pulmonary vessels.

Original languageEnglish (US)
Pages (from-to)2106-2111
Number of pages6
JournalJournal of applied physiology
Volume75
Issue number5
DOIs
StatePublished - 1993

Keywords

  • arterioles
  • dogs
  • pulmonary circulation
  • pulmonary microcirculation
  • pulmonary vascular distensibility
  • venules
  • videomicroscopy

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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    Hillier, S. C., Godbey, P. S., Hanger, C. C., Graham, J. A., Presson, R. G., Okada, O., Linehan, J. H., Dawson, C. A., & Wagner, W. W. (1993). Direct measurement of pulmonary microvascular distensibility. Journal of applied physiology, 75(5), 2106-2111. https://doi.org/10.1152/jappl.1993.75.5.2106