TY - JOUR
T1 - Direct measurement of the time-dependent mechanical response of HPMC and PEO compacts during swelling
AU - Hewlett, Kathryn Otim
AU - L'Hote-Gaston, Jennifer
AU - Radler, Michael
AU - Shull, Kenneth R.
N1 - Funding Information:
This work was supported through the National Science Foundation through Grant CMMI-0900586 .
PY - 2012/9/15
Y1 - 2012/9/15
N2 - Mechanical indentation is used to measure the time dependent mechanical properties of three model compact formulations during swelling in aqueous media. The formulations are based on polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC) and a PEO/HPMC blend. The technique is sensitive to changes in compact thickness and mechanical response and is used to characterize changes in the mechanical properties of the model compacts during the swelling process. The gel thickness and the effective elastic modulus of the gel layer are obtained from the load/displacement relationship during initial indentation. The HPMC and hybrid compacts showed significantly more swelling (110%) than the PEO compact (67%). Viscoelastic properties of the gel layer are determined throughout the swelling process by an oscillatory indentation method. Results show the complex modulus of all three compacts decreasing by approximately an order of magnitude over the course of swelling for 6 h. The measurement techniques presented here can easily be extended to more complex systems.
AB - Mechanical indentation is used to measure the time dependent mechanical properties of three model compact formulations during swelling in aqueous media. The formulations are based on polyethylene oxide (PEO), hydroxypropyl methylcellulose (HPMC) and a PEO/HPMC blend. The technique is sensitive to changes in compact thickness and mechanical response and is used to characterize changes in the mechanical properties of the model compacts during the swelling process. The gel thickness and the effective elastic modulus of the gel layer are obtained from the load/displacement relationship during initial indentation. The HPMC and hybrid compacts showed significantly more swelling (110%) than the PEO compact (67%). Viscoelastic properties of the gel layer are determined throughout the swelling process by an oscillatory indentation method. Results show the complex modulus of all three compacts decreasing by approximately an order of magnitude over the course of swelling for 6 h. The measurement techniques presented here can easily be extended to more complex systems.
KW - Drug release compacts
KW - Indentation
KW - Mechanical properties
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U2 - 10.1016/j.ijpharm.2012.05.001
DO - 10.1016/j.ijpharm.2012.05.001
M3 - Article
C2 - 22609126
AN - SCOPUS:84864145751
SN - 0378-5173
VL - 434
SP - 494
EP - 501
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 1-2
ER -