Direct observation of morphological tranformation from twisted ribbons into helical ribbons

E. Thomas Pashuck, Samuel I. Stupp

Research output: Contribution to journalArticlepeer-review

230 Scopus citations


We report on the direct observation of a nanostructural transformation from a twisted ribbon to a helical ribbon in supramolecular assemblies of peptide amphiphiles. Using cryogenic electron microscopy, a peptide amphiphile molecule containing aromatic residues was found to first assemble into short twisted ribbons in the time range of seconds, which then elongate in the time scale of minutes, and finally transform into helical ribbons over the course of weeks. By synthesizing an analogous molecule without the aromatic side groups, it was found that a cylindrical nanostructure is formed that does not undergo any transitions during the same time period. The study of metastable states in peptide aggregation can contribute to our understanding of amyloid-related diseases, such as Alzheimers disease.

Original languageEnglish (US)
Pages (from-to)8819-8821
Number of pages3
JournalJournal of the American Chemical Society
Issue number26
StatePublished - Jul 7 2010

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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