TY - JOUR
T1 - Direct T-cell effects of minoxidii
AU - Fiedler, Virginia C.
AU - Buys, Cunera M.
PY - 1988
Y1 - 1988
N2 - Minoxidil has been shown to induce hair regrowth in alopecia areata1-4 by mechanisms that remain largely unknown. Alopecia areata is histologically characterized by miniaturized follicles with varying degrees of degeneration5 and by a dense perifollicular infiltration of T lymphocytes (helper, suppressor, and activated), Langerhans cells, and monocytes.6,7 T lymphocytes appear to be the predominant cell type in the perifollicular infiltrates and, by implication, may be of pathogenic significance in the hair loss process. Changes in perifollicular T-cell and activated T-cell populations have been found after treatment with minoxidil.7 Responders to topical 5% minoxidil treatment (ie, those patients who had terminal hair regrowth) have shown decreases in tissue T cells and simultaneous increases in peripheral blood T cells.7.
AB - Minoxidil has been shown to induce hair regrowth in alopecia areata1-4 by mechanisms that remain largely unknown. Alopecia areata is histologically characterized by miniaturized follicles with varying degrees of degeneration5 and by a dense perifollicular infiltration of T lymphocytes (helper, suppressor, and activated), Langerhans cells, and monocytes.6,7 T lymphocytes appear to be the predominant cell type in the perifollicular infiltrates and, by implication, may be of pathogenic significance in the hair loss process. Changes in perifollicular T-cell and activated T-cell populations have been found after treatment with minoxidil.7 Responders to topical 5% minoxidil treatment (ie, those patients who had terminal hair regrowth) have shown decreases in tissue T cells and simultaneous increases in peripheral blood T cells.7.
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U2 - 10.1016/0738-081X(88)90079-X
DO - 10.1016/0738-081X(88)90079-X
M3 - Article
C2 - 3265075
AN - SCOPUS:0024098370
SN - 0738-081X
VL - 6
SP - 148
EP - 151
JO - Clinics in Dermatology
JF - Clinics in Dermatology
IS - 4
ER -