Direct T-cell effects of minoxidii

Virginia C. Fiedler*, Cunera M. Buys

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Minoxidil has been shown to induce hair regrowth in alopecia areata1-4 by mechanisms that remain largely unknown. Alopecia areata is histologically characterized by miniaturized follicles with varying degrees of degeneration5 and by a dense perifollicular infiltration of T lymphocytes (helper, suppressor, and activated), Langerhans cells, and monocytes.6,7 T lymphocytes appear to be the predominant cell type in the perifollicular infiltrates and, by implication, may be of pathogenic significance in the hair loss process. Changes in perifollicular T-cell and activated T-cell populations have been found after treatment with minoxidil.7 Responders to topical 5% minoxidil treatment (ie, those patients who had terminal hair regrowth) have shown decreases in tissue T cells and simultaneous increases in peripheral blood T cells.7.

Original languageEnglish (US)
Pages (from-to)148-151
Number of pages4
JournalClinics in Dermatology
Volume6
Issue number4
DOIs
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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