Direct-write dip-pen nanolithography of proteins on modified silicon oxide surfaces

Jung Hyurk Lim, David S. Ginger, Ki Bum Lee, Jungseok Heo, Jwa Min Nam, Chad A. Mirkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

206 Scopus citations


Pen a nanoletter: Direct-write dip-pen nanolithography (DPN) has been used to generate protein nanostructures on modified silicon oxide surfaces. This technique offers control over feature size at the 50-550 nm scale. The bioactivity of the proteins remains intact and has been studied by fluorescence microscopy (see picture).

Original languageEnglish (US)
Pages (from-to)2309-2312
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number20
StatePublished - May 25 2003


  • Biorecognition
  • Direct-write patterns
  • Nanostructures
  • Proteins
  • Surface chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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