Directed assembly of periodic materials from protein and oligonucleotide-modified nanoparticle building blocks

So Jung Park, Anne A. Lazarides, Chad A. Mirkin*, Robert L. Letsinger

*Corresponding author for this work

Research output: Contribution to journalArticle

179 Scopus citations

Abstract

DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin (see picture). The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

Original languageEnglish (US)
Pages (from-to)2909-2912
Number of pages4
JournalAngewandte Chemie - International Edition
Volume40
Issue number15
DOIs
StatePublished - Aug 3 2001

Keywords

  • DNA structures
  • Nanostructures
  • Oligonucleotides
  • Proteins
  • Small-angle X-ray scattering

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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