Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface

Kristopher A. Kilian*, Milan Mrksich

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Sticky situation: The differentiation of mesenchymal stem cells can be influenced by the affinity and density of an immobilized ligand for the integrin receptors. Cells adherent to monolayers that present the high-affinity, cyclic-RGD peptide (left) show increased expression of osteogenic markers, while cells on monolayers presenting the lower-affinity, linear-RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low density of the ligand.

Original languageEnglish (US)
Pages (from-to)4891-4895
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number20
DOIs
StatePublished - May 14 2012

Keywords

  • biomaterials
  • monolayers
  • peptides
  • self-assembled monolayers
  • stem cells

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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