Directly measuring absolute flow speed by frequency-domain laser speckle imaging

Hao Li, Qi Liu, Hongyang Lu, Yao Li, Hao F. Zhang, Shanbao Tong*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Laser speckle contrast imaging (LSCI) is a simple yet powerful tool to image blood flow. However, traditional LSCI has limited quantitative analysis capabilities due to various factors affecting flow speed evaluation, including illumination intensity, scattering from static tissues, and mathematical complexity of blood flow estimation. Here, we present a frequency-domain laser speckle imaging (FDLSI) method that can directly measure absolute flow speed. In phantom experiments, the measured flow speed agreed well with the preset actual values (10% deviation). Furthermore, in vivo experiments demonstrated that FDLSI was minimally affected by illumination condition changes.

Original languageEnglish (US)
Pages (from-to)21079-21087
Number of pages9
JournalOptics Express
Issue number17
StatePublished - Aug 25 2014

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics


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