Disagreement on foundational principles of biological aging

Vadim N. Gladyshev; Benjamin Anderson; Hanna Barlit; Benjamin Barré; Samuel Beck; Bahareh Behrouz; Daniel W. Belsky; Amandine Chaix; Manish Chamoli; Brian H. Chen; Kaiyang Cheng; Jane Chuprin; Gary A. Churchill; Andrea Cipriano; Alex Colville; Joris Deelen; Yuri Deigin; Ke Huan K. Edmonds; Bradley W. English; Ruogu Fang; Michael Florea; Iosif M. Gershteyn; Diljeet Gill; Laura H. Goetz; Vera Gorbunova; Patrick T. Griffin; Steve Horvath; Martin Borch Jensen; Xin Jin; Sara Jovanovska; Kathrin M. Kajderowicz; Tomoko Kasahara; Csaba Kerepesi; Subhash Kulkarni; Vyacheslav M. Labunskyy; Morgan E. Levine; Sergiy Libert; J. Yuyang Lu; Yuancheng Ryan Lu; Riccardo E. Marioni; Brianah M. McCoy; Wayne Mitchell; Mahdi Moqri; Farzaneh Nasirian; Peter Niimi; Hamilton Se Hwee Oh; Brian Okundaye; Andrey A. Parkhitko; Leonid Peshkin; Mia Petljak; Jesse R. Poganik; Glen Pridham; Daniel E.L. Promislow; Weronika Prusisz; Margaux Quiniou; Ken Raj; Daniel Richard; Jose Luis Ricon; Jarod Rutledge; Morten Scheibye-Knudsen; Nicholas J. Schork; Andrei Seluanov; Michael Shadpour; Anastasia V. Shindyapina; Steven R. Shuken; Sruthi Sivakumar; Thomas Stoeger; Ayumu Sugiura; Nadia R. Sutton; Alexander Suvorov; Andrei E. Tarkhov; Emma C. Teeling; Alexandre Trapp; Alexander Tyshkovskiy; Maximilian Unfried; Cavin K. Ward-Caviness; Sun Hee Yim; Kejun Ying; Jeffrey Yunes; Bohan Zhang; Alex Zhavoronkov

doi:10.1093/pnasnexus/pgae499

Disagreement on foundational principles of biological aging

Vadim N. Gladyshev^*, Benjamin Anderson, Hanna Barlit, Benjamin Barré, Samuel Beck, Bahareh Behrouz, Daniel W. Belsky, Amandine Chaix, Manish Chamoli, Brian H. Chen, Kaiyang Cheng, Jane Chuprin, Gary A. Churchill, Andrea Cipriano, Alex Colville, Joris Deelen, Yuri Deigin, Ke Huan K. Edmonds, Bradley W. English, Ruogu FangMichael Florea, Iosif M. Gershteyn, Diljeet Gill, Laura H. Goetz, Vera Gorbunova, Patrick T. Griffin, Steve Horvath, Martin Borch Jensen, Xin Jin, Sara Jovanovska, Kathrin M. Kajderowicz, Tomoko Kasahara, Csaba Kerepesi, Subhash Kulkarni, Vyacheslav M. Labunskyy, Morgan E. Levine, Sergiy Libert, J. Yuyang Lu, Yuancheng Ryan Lu, Riccardo E. Marioni, Brianah M. McCoy, Wayne Mitchell, Mahdi Moqri, Farzaneh Nasirian, Peter Niimi, Hamilton Se Hwee Oh, Brian Okundaye, Andrey A. Parkhitko, Leonid Peshkin, Mia Petljak, Jesse R. Poganik, Glen Pridham, Daniel E.L. Promislow, Weronika Prusisz, Margaux Quiniou, Ken Raj, Daniel Richard, Jose Luis Ricon, Jarod Rutledge, Morten Scheibye-Knudsen, Nicholas J. Schork, Andrei Seluanov, Michael Shadpour, Anastasia V. Shindyapina, Steven R. Shuken, Sruthi Sivakumar, Thomas Stoeger, Ayumu Sugiura, Nadia R. Sutton, Alexander Suvorov, Andrei E. Tarkhov, Emma C. Teeling, Alexandre Trapp, Alexander Tyshkovskiy, Maximilian Unfried, Cavin K. Ward-Caviness, Sun Hee Yim, Kejun Ying, Jeffrey Yunes, Bohan Zhang, Alex Zhavoronkov

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

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Abstract

To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.

Original language	English (US)
Article number	pgae499
Journal	PNAS Nexus
Volume	3
Issue number	12
DOIs	https://doi.org/10.1093/pnasnexus/pgae499
State	Published - Dec 1 2024

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Gladyshev, V. N., Anderson, B., Barlit, H., Barré, B., Beck, S., Behrouz, B., Belsky, D. W., Chaix, A., Chamoli, M., Chen, B. H., Cheng, K., Chuprin, J., Churchill, G. A., Cipriano, A., Colville, A., Deelen, J., Deigin, Y., Edmonds, K. H. K., English, B. W., ... Zhavoronkov, A. (2024). Disagreement on foundational principles of biological aging. PNAS Nexus, 3(12), Article pgae499. https://doi.org/10.1093/pnasnexus/pgae499

@article{6ba12597486b4b069995d3a7deaa02a5,

title = "Disagreement on foundational principles of biological aging",

abstract = "To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.",

author = "Gladyshev, {Vadim N.} and Benjamin Anderson and Hanna Barlit and Benjamin Barr{\'e} and Samuel Beck and Bahareh Behrouz and Belsky, {Daniel W.} and Amandine Chaix and Manish Chamoli and Chen, {Brian H.} and Kaiyang Cheng and Jane Chuprin and Churchill, {Gary A.} and Andrea Cipriano and Alex Colville and Joris Deelen and Yuri Deigin and Edmonds, {Ke Huan K.} and English, {Bradley W.} and Ruogu Fang and Michael Florea and Gershteyn, {Iosif M.} and Diljeet Gill and Goetz, {Laura H.} and Vera Gorbunova and Griffin, {Patrick T.} and Steve Horvath and Jensen, {Martin Borch} and Xin Jin and Sara Jovanovska and Kajderowicz, {Kathrin M.} and Tomoko Kasahara and Csaba Kerepesi and Subhash Kulkarni and Labunskyy, {Vyacheslav M.} and Levine, {Morgan E.} and Sergiy Libert and {Yuyang Lu}, J. and Lu, {Yuancheng Ryan} and Marioni, {Riccardo E.} and McCoy, {Brianah M.} and Wayne Mitchell and Mahdi Moqri and Farzaneh Nasirian and Peter Niimi and Oh, {Hamilton Se Hwee} and Brian Okundaye and Parkhitko, {Andrey A.} and Leonid Peshkin and Mia Petljak and Poganik, {Jesse R.} and Glen Pridham and Promislow, {Daniel E.L.} and Weronika Prusisz and Margaux Quiniou and Ken Raj and Daniel Richard and Ricon, {Jose Luis} and Jarod Rutledge and Morten Scheibye-Knudsen and Schork, {Nicholas J.} and Andrei Seluanov and Michael Shadpour and Shindyapina, {Anastasia V.} and Shuken, {Steven R.} and Sruthi Sivakumar and Thomas Stoeger and Ayumu Sugiura and Sutton, {Nadia R.} and Alexander Suvorov and Tarkhov, {Andrei E.} and Teeling, {Emma C.} and Alexandre Trapp and Alexander Tyshkovskiy and Maximilian Unfried and Ward-Caviness, {Cavin K.} and Yim, {Sun Hee} and Kejun Ying and Jeffrey Yunes and Bohan Zhang and Alex Zhavoronkov",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024. Published by Oxford University Press on behalf of National Academy of Sciences.",

year = "2024",

month = dec,

day = "1",

doi = "10.1093/pnasnexus/pgae499",

language = "English (US)",

volume = "3",

journal = "PNAS Nexus",

issn = "2752-6542",

publisher = "National Academy of Sciences",

number = "12",

}

Gladyshev, VN, Anderson, B, Barlit, H, Barré, B, Beck, S, Behrouz, B, Belsky, DW, Chaix, A, Chamoli, M, Chen, BH, Cheng, K, Chuprin, J, Churchill, GA, Cipriano, A, Colville, A, Deelen, J, Deigin, Y, Edmonds, KHK, English, BW, Fang, R, Florea, M, Gershteyn, IM, Gill, D, Goetz, LH, Gorbunova, V, Griffin, PT, Horvath, S, Jensen, MB, Jin, X, Jovanovska, S, Kajderowicz, KM, Kasahara, T, Kerepesi, C, Kulkarni, S, Labunskyy, VM, Levine, ME, Libert, S, Yuyang Lu, J, Lu, YR, Marioni, RE, McCoy, BM, Mitchell, W, Moqri, M, Nasirian, F, Niimi, P, Oh, HSH, Okundaye, B, Parkhitko, AA, Peshkin, L, Petljak, M, Poganik, JR, Pridham, G, Promislow, DEL, Prusisz, W, Quiniou, M, Raj, K, Richard, D, Ricon, JL, Rutledge, J, Scheibye-Knudsen, M, Schork, NJ, Seluanov, A, Shadpour, M, Shindyapina, AV, Shuken, SR, Sivakumar, S, Stoeger, T, Sugiura, A, Sutton, NR, Suvorov, A, Tarkhov, AE, Teeling, EC, Trapp, A, Tyshkovskiy, A, Unfried, M, Ward-Caviness, CK, Yim, SH, Ying, K, Yunes, J, Zhang, B & Zhavoronkov, A 2024, 'Disagreement on foundational principles of biological aging', PNAS Nexus, vol. 3, no. 12, pgae499. https://doi.org/10.1093/pnasnexus/pgae499

TY - JOUR

T1 - Disagreement on foundational principles of biological aging

AU - Gladyshev, Vadim N.

AU - Anderson, Benjamin

AU - Barlit, Hanna

AU - Barré, Benjamin

AU - Beck, Samuel

AU - Behrouz, Bahareh

AU - Belsky, Daniel W.

AU - Chaix, Amandine

AU - Chamoli, Manish

AU - Chen, Brian H.

AU - Cheng, Kaiyang

AU - Chuprin, Jane

AU - Churchill, Gary A.

AU - Cipriano, Andrea

AU - Colville, Alex

AU - Deelen, Joris

AU - Deigin, Yuri

AU - Edmonds, Ke Huan K.

AU - English, Bradley W.

AU - Fang, Ruogu

AU - Florea, Michael

AU - Gershteyn, Iosif M.

AU - Gill, Diljeet

AU - Goetz, Laura H.

AU - Gorbunova, Vera

AU - Griffin, Patrick T.

AU - Horvath, Steve

AU - Jensen, Martin Borch

AU - Jin, Xin

AU - Jovanovska, Sara

AU - Kajderowicz, Kathrin M.

AU - Kasahara, Tomoko

AU - Kerepesi, Csaba

AU - Kulkarni, Subhash

AU - Labunskyy, Vyacheslav M.

AU - Levine, Morgan E.

AU - Libert, Sergiy

AU - Yuyang Lu, J.

AU - Lu, Yuancheng Ryan

AU - Marioni, Riccardo E.

AU - McCoy, Brianah M.

AU - Mitchell, Wayne

AU - Moqri, Mahdi

AU - Nasirian, Farzaneh

AU - Niimi, Peter

AU - Oh, Hamilton Se Hwee

AU - Okundaye, Brian

AU - Parkhitko, Andrey A.

AU - Peshkin, Leonid

AU - Petljak, Mia

AU - Poganik, Jesse R.

AU - Pridham, Glen

AU - Promislow, Daniel E.L.

AU - Prusisz, Weronika

AU - Quiniou, Margaux

AU - Raj, Ken

AU - Richard, Daniel

AU - Ricon, Jose Luis

AU - Rutledge, Jarod

AU - Scheibye-Knudsen, Morten

AU - Schork, Nicholas J.

AU - Seluanov, Andrei

AU - Shadpour, Michael

AU - Shindyapina, Anastasia V.

AU - Shuken, Steven R.

AU - Sivakumar, Sruthi

AU - Stoeger, Thomas

AU - Sugiura, Ayumu

AU - Sutton, Nadia R.

AU - Suvorov, Alexander

AU - Tarkhov, Andrei E.

AU - Teeling, Emma C.

AU - Trapp, Alexandre

AU - Tyshkovskiy, Alexander

AU - Unfried, Maximilian

AU - Ward-Caviness, Cavin K.

AU - Yim, Sun Hee

AU - Ying, Kejun

AU - Yunes, Jeffrey

AU - Zhang, Bohan

AU - Zhavoronkov, Alex

PY - 2024/12/1

Y1 - 2024/12/1

N2 - To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.

AB - To gain insight into how researchers of aging perceive the process they study, we conducted a survey among experts in the field. While highlighting some common features of aging, the survey exposed broad disagreement on the foundational issues. What is aging? What causes it? When does it begin? What constitutes rejuvenation? Not only was there no consensus on these and other core questions, but none of the questions received a majority opinion—even regarding the need for consensus itself. Despite many researchers believing they understand aging, their understanding diverges considerably. Importantly, as different processes are labeled as “aging” by researchers, different experimental approaches are prioritized. The survey shed light on the need to better define which aging processes this field should target and what its goals are. It also allowed us to categorize contemporary views on aging and rejuvenation, revealing critical, yet largely unanswered, questions that appear disconnected from the current research focus. Finally, we discuss ways to address the disagreement, which we hope will ultimately aid progress in the field.

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DO - 10.1093/pnasnexus/pgae499

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SN - 2752-6542

VL - 3

JO - PNAS Nexus

JF - PNAS Nexus

IS - 12

M1 - pgae499

ER -

Disagreement on foundational principles of biological aging

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