Discordance among cell-mediated cytolytic mechanisms in cancer patients: Importance of the assay system

W. J. Catalona, T. L. Ratliff, R. E. McCool

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

ADCC and SCMC directed against Chang cell targets that are mediated by lymphocytes having properties characteristic of K cells were impaired in cancer patients. In contrast, ADCC directed against CRBC targets that is mediated by both K cells and macrophages was normal in cancer patients, whereas SCMC against CRBC that is mediated primarily by macrophages was increased. Thus, there was a discordance among cytotoxic mechanisms in cancer patients with K cell-mediated cytotoxic function being impaired and macrophage-mediated cytotoxicity being enhanced. Regression analysis suggested that these perturbations of cytotoxic function occurred independently. Cancer patients had an increased proportion of circulating macrophages and a decreased proportion of eosinophils, but these abnormalities did not correlate significantly with ADCC or SCMC.

Original languageEnglish (US)
Pages (from-to)1009-1014
Number of pages6
JournalJournal of Immunology
Volume122
Issue number3
StatePublished - Jan 1 1979

ASJC Scopus subject areas

  • Immunology

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