Discordance in fibrosis staging between liver biopsy and transient elastography using the FibroScan XL probe

Robert P. Myers*, Gilles Pomier-Layrargues, Richard Kirsch, Aaron Pollett, Melanie Beaton, Mark Levstik, Andres Duarte-Rojo, David Wong, Pam Crotty, Magdy Elkashab

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

119 Scopus citations

Abstract

Background & Aims: The FibroScan XL probe facilitates liver stiffness measurement (LSM) by transient elastography (TE) in obese patients, yet factors affecting its accuracy have not been described. Our objectives were to examine the prevalence, risk factors, and causes of discordance between fibrosis estimated by the FibroScan XL probe and biopsy. Methods: Two hundred and ten patients with chronic liver disease (45% viral hepatitis, 55% nonalcoholic fatty liver disease (NAFLD) and a body mass index (BMI) ≥28 kg/m 2) underwent liver biopsy and TE with the FibroScan XL probe. Predictors of discordance ≥2 fibrosis stages between measures, which occurred in 11% of patients (n = 24), were identified by comparing patient, TE, and biopsy characteristics of discordant and non-discordant cases. Results: Fibrosis estimated by the FibroScan XL probe was greater than biopsy in 75% (18/24) of discordant cases. Although biopsy quality was not associated with discordance, discordant cases were less likely to have ≥10 valid shots (75% vs. 97%; p = 0.001), a success rate ≥60% (67% vs. 95%; p <0.0005), and an interquartile range over median liver stiffness (IQR/M) <21% (37% vs. 57%; p = 0.07) than non-discordant cases. However, only increased BMI (odds ratio [OR] 1.09 per kg/m 2; 95% confidence interval [CI] 1.01-1.18; p = 0.04) was independently associated with discordance; liver stiffness was of borderline significance (OR 1.73 per log 10-transformed value; 95% CI 0.95-3.18; p = 0.08). Discordance was 4- to 5-fold more frequent among patients with severe obesity (BMI ≥40 kg/m 2: 32% vs. 8%) and liver stiffness above the median of 7.0 kPa (20% vs. 4%; both p <0.0005). Conclusions: Discordance between liver fibrosis estimated by biopsy and TE using the FibroScan XL probe was infrequent in this obese population. Patients with severe obesity and elevated liver stiffness have the greatest risk of discordance.

Original languageEnglish (US)
Pages (from-to)564-570
Number of pages7
JournalJournal of Hepatology
Volume56
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • Biomarker
  • Biopsy
  • Fibrosis
  • Stiffness

ASJC Scopus subject areas

  • Hepatology

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