Discovering translational biomarkers in neurodevelopmental disorders

Mustafa Sahin; Stephanie R. Jones; John A. Sweeney; Elizabeth Berry-Kravis; Barry W. Connors; Joshua B. Ewen; Adam L. Hartman; April R. Levin; William Z. Potter; Laura A. Mamounas

doi:10.1038/d41573-018-00010-7

Discovering translational biomarkers in neurodevelopmental disorders

Mustafa Sahin^*, Stephanie R. Jones, John A. Sweeney, Elizabeth Berry-Kravis, Barry W. Connors, Joshua B. Ewen, Adam L. Hartman, April R. Levin, William Z. Potter, Laura A. Mamounas

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Investment in drug development for neurodevelopmental disorders has suffered from recent failures in clinical trials that were based on promising preclinical findings. Here, we discuss development and validation of translational biomarkers of neurodevelopmental disorders that can enable more informative clinical experiments and translational success in these diseases.

Original language	English (US)
Pages (from-to)	235-236
Number of pages	2
Journal	Nature Reviews Drug Discovery
Volume	18
DOIs	https://doi.org/10.1038/d41573-018-00010-7
State	Published - 2019

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1038/d41573-018-00010-7

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title = "Discovering translational biomarkers in neurodevelopmental disorders",

abstract = "Investment in drug development for neurodevelopmental disorders has suffered from recent failures in clinical trials that were based on promising preclinical findings. Here, we discuss development and validation of translational biomarkers of neurodevelopmental disorders that can enable more informative clinical experiments and translational success in these diseases.",

author = "Mustafa Sahin and Jones, {Stephanie R.} and Sweeney, {John A.} and Elizabeth Berry-Kravis and Connors, {Barry W.} and Ewen, {Joshua B.} and Hartman, {Adam L.} and Levin, {April R.} and Potter, {William Z.} and Mamounas, {Laura A.}",

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AU - Sahin, Mustafa

AU - Jones, Stephanie R.

AU - Sweeney, John A.

AU - Berry-Kravis, Elizabeth

AU - Connors, Barry W.

AU - Ewen, Joshua B.

AU - Hartman, Adam L.

AU - Levin, April R.

AU - Potter, William Z.

AU - Mamounas, Laura A.

PY - 2019

Y1 - 2019

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Discovering translational biomarkers in neurodevelopmental disorders

Abstract

ASJC Scopus subject areas

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