Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound

Salida Mirzoeva, Anu Sawkar, Magdalena Zasadzki, Ling Guo, Anastasia V. Velentza, Vincent Dunlap, Jean Jacques Bourguignonl, Helena Ramstrom, Jacques Haiech, Linda J. Van Eldik, D. M. Watterson*

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Excessive glial activation, with overproduction of cytokines and oxidative stress products, is detrimental and a hallmark of neurodegenerative disease pathology. Suppression of glial activation is a potential therapeutic approach, and protein kinases are targets of some antiinflammatory drugs. To address an unmet need for selective inhibitors of glial activation, we developed a novel 3-amino-6-phenylpyridazine derivative that selectively blocks increased IL-1β, iNOS, and NO production by activated glia, without inhibition of potentially beneficial glial functions.

Original languageEnglish (US)
Pages (from-to)563-566
Number of pages4
JournalJournal of Medicinal Chemistry
Volume45
Issue number3
DOIs
StatePublished - Jan 31 2002

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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    Mirzoeva, S., Sawkar, A., Zasadzki, M., Guo, L., Velentza, A. V., Dunlap, V., Bourguignonl, J. J., Ramstrom, H., Haiech, J., Van Eldik, L. J., & Watterson, D. M. (2002). Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. Journal of Medicinal Chemistry, 45(3), 563-566. https://doi.org/10.1021/jm015573g