Discovery of a murine model of clinical PAH: Mission impossible?

Zhiyu Dai, You Yang Zhao*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) is a lung vascular disease characterized with a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling resulting in right heart failure and premature death. In this brief review, we document the recent advances in identifying genetically modified murine models of PH, with a focus on the recent discovery of the mouse model of Tie2 Cre-mediated deletion of prolyl hydroxylase 2, which exhibits progressive obliterative vascular remodeling, severe PAH, and right heart failure, thus recapitulating many of the features of clinical PAH. We will also discuss the translational potential of recent findings arising from experimental studies of murine PH models.

Original languageEnglish (US)
Pages (from-to)229-236
Number of pages8
JournalTrends in Cardiovascular Medicine
Volume27
Issue number4
DOIs
StatePublished - May 2017

Keywords

  • Animal model
  • Endothelium
  • Hypoxia inducible factor
  • Prolyl hydroxylases
  • Vascular remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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