Discovery of candidate tumor biomarkers for treatment with intraperitoneal chemotherapy for ovarian cancer

Brandon Luke L. Seagle, Kevin H. Eng, Judy Y. Yeh, Monica Dandapani, Emily Schiller, Robert Samuelson, Kunle Odunsi, Shohreh Shahabi*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Tumor mRNA expression was used to discover genes associated with worse survival or no survival benefit after intraperitoneal (IP) chemotherapy. Data for high grade serous ovarian cancer patients treated with IP (n = 90) or IV-only (n = 398) chemotherapy was obtained from The Cancer Genome Atlas. Progression free survival (PFS) and overall survival (OS) were compared between IP and IV groups using Kaplan-Meier analysis and Cox regression. Validations were performed by analyses of microarray and RNA-Seq mRNA expression data. PFS and OS were compared between IP and IV groups by permutation testing stratified by gene expression. P-values are two-tailed. IP chemotherapy increased PFS (26.7 vs 16.0 months, HR 0.43 (0.28-0.66), p = 0.0001) and OS (49.6 vs 38.2 months, HR 0.46 (0.25-0.83), p = 0.01). Increased expression of NCAM2 and TSHR and decreased expression of GCNT1 was associated with decreased PFS and OS after IV chemotherapy (p < 0.05). High tumor expression of LMAN2, FZD4, FZD5, or STT3A was associated with no significant PFS increase after IP compared to IV chemotherapy. Low expression of APC2 and high expression of FUT9 was associated with 5.5 and 7.2 months, respectively, decreased OS after IP compared to IV chemotherapy (p ≤ 0.007).

Original languageEnglish (US)
Article number21591
JournalScientific reports
Volume6
DOIs
StatePublished - Feb 17 2016

ASJC Scopus subject areas

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    Seagle, B. L. L., Eng, K. H., Yeh, J. Y., Dandapani, M., Schiller, E., Samuelson, R., Odunsi, K., & Shahabi, S. (2016). Discovery of candidate tumor biomarkers for treatment with intraperitoneal chemotherapy for ovarian cancer. Scientific reports, 6, [21591]. https://doi.org/10.1038/srep21591