@article{f036ba56883944b0b0e667ad07939be3,
title = "Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments",
abstract = "Here we present a virtual docking screen of 1648 commercially available covalent fragments, and identified covalent inhibitors of cysteine protease cathepsin L. These inhibitors did not inhibit closely related protease cathepsin B. Thus, we have established virtual docking of covalent fragments as an approach to discover covalent enzyme inhibitors.",
author = "Chowdhury, {Sandipan Roy} and Steven Kennedy and Kai Zhu and Rama Mishra and Patrick Chuong and Nguyen, {Alyssa uyen} and Kathman, {Stefan G.} and Statsyuk, {Alexander V.}",
note = "Funding Information: This work was supported in part by National Institutes of Health Awards R01GM115632 (to A.V.S.) and T32GM105538 (to S.G.K.), William & Ella Owens Research Foundation, and the University of Houston. A.V.S. is a Pew Scholar in the Biomedical Sciences, supported by the Pew Charitable Trusts . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health . The authors declare that they have no conflicts of interest with the contents of this article. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2019",
month = jan,
day = "1",
doi = "10.1016/j.bmcl.2018.11.019",
language = "English (US)",
volume = "29",
pages = "36--39",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "1",
}