Discovery of novel Mnk inhibitors using mutation-based induced-fit virtual high-throughput screening

Keyphrases

• Mnk Inhibitors 100%
• Mutation-based 100%
• Induced Fit 100%
• High-throughput Virtual Screening 100%
• Acute Myeloid Leukemia 75%
• MNK1 75%
• Mitogen-activated Protein Kinase 25%
• Phosphorylation 25%
• Amino Acids 25%
• Leukemogenesis 25%
• Hit Compound 25%
• Antileukemic Activity 25%
• In Silico Screening 25%
• Downstream Effectors 25%
• Kinase Cascade 25%
• Cellular Assay 25%
• Biochemical Assay 25%
• Structure-based Drug Design 25%
• Eukaryotic Translation Initiation Factor 4E (eIF4E) 25%
• Rational Structure 25%
• ATP Binding Site 25%
• Docking Simulation 25%

Pharmacology, Toxicology and Pharmaceutical Science

• High-Throughput Screening 100%
• Acute Myeloid Leukemia 100%
• Phosphotransferase 66%
• Drug Development 33%
• Binding Site 33%
• Amino Acid 33%
• Leukemogenesis 33%
• Initiation Factor 4E 33%
• Adenosine Triphosphate 33%

Biochemistry, Genetics and Molecular Biology

• Myeloid 100%
• High Throughput Screening 100%
• Crystal Structure 33%
• Eukaryotic Initiation Factor 33%
• Amino Acids 33%
• Binding Site 33%
• Adenosine Triphosphate 33%
• Kinase 33%
• Phosphotransferase 33%
• Mitogen-Activated Protein Kinase 33%