The discovery of the Clock mutant mouse in 1994 and the identification and cloning of the gene underlying the mutation, named Clock, was a landmark finding in the history of the field of mammalian circadian rhythms. Unexpected at the time, the discovery of the Clock mutant animal would eventually lead to an entire new approach to the study and treatment of obesity. The report in 2005 that the Clock mutant animal is obese and shows signs of the metabolic syndrome opened up an entire new field of obesity research. Although still in the early stages of discovery, linking circadian clock genes to energy regulation has clear implications for future studies on body weight regulation at the mechanistic level, as well as for the development of new therapeutic approaches for combatting the epidemic of obesity, as well as metabolic disorders, including diabetes.
ASJC Scopus subject areas
- General Medicine
- General Biochemistry, Genetics and Molecular Biology