Disease characteristics and clinical outcomes in patients aged less than 40 with chronic lymphocytic leukemia

Bartlomiej M. Getta*, Sean Devlin, Jae H. Park, Martin S. Tallman, Ellin Berman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Outcomes in very young CLL patients (age ≤40) are not well characterized. We compared 71 consecutive patients aged ≤40 with 142 “older” matched patients >40 from our institution and used SEER database as an independent comparison group. Patients in the two age groups were diagnosed at similar Rai stage. At diagnosis, very young patients had a similar rate of adverse cytogenetics, IGHV mutation and ZAP70 expression and had lower beta-2-microglobulin and a lower incidence of second malignancies. There was no difference between the groups with respect to incidence of autoimmune manifestations, family history of lymphoma, time to initiation of CLL therapy, response to therapy, or Richter's transformation. Variables including un-mutated IGHV and elevated LDH were associated with shorter times to treatment initiation in both groups. A trend to longer 5-year survival for very young patients in our institution (93% v 82%, p = 0.082) was validated by SEER data.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalLeukemia Research
Volume65
DOIs
StatePublished - Feb 2018

Funding

Consent to perform this work was obtained from the Memorial Sloan Kettering Cancer Center Institutional Review Board and research was performed in accordance with HIPAA regulations. Surveillance, Epidemiology, and End Results (SEER) Program ( www.seer.cancer.gov ) SEER*Stat Database: Populations – Total U.S. (1990–2005). Total U.S., 1969–2013 Counties, National Cancer Institute, DCCPS, Surveillance Research Program, Surveillance Systems Branch, released October 2014. Appendix A

Keywords

  • Chronic lymphocytic leukemia
  • Richter's transformation
  • Young

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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