Disease damage and low bone mineral density: An analysis of women with systemic lupus erythematosus ever and never receiving corticosteroids

C. Lee*, O. Almagor, D. D. Dunlop, S. Manzi, S. Spies, A. B. Chadha, R. Ramsey-Goldman

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Objectives. To evaluate the relationship between disease damage and bone mineral density (BMD) in women with systemic lupus erythematosus (SLE). Methods. A cross-sectional study was conducted among 307 women with SLE. Patients attended a single clinic visit that included an interview, physical examination, laboratory testing and BMD measurements (hip and/or lumbar spine). Women were stratified by the Systemic Lupus International Collaborating Clinics/American College of Rheumatology cumulative disease damage index (SDI)≥1(Damage) vs SDI=0 (No Damage),and prior use of corticosteroids (CS), yielding four groups: (1) Damage/CS+ (n=138), (2) Damage/CS- (n=23), (3) no Damage/CS- (n=100), and (4) no Damage/CS- (n=46). Results. Mean age at SLE diagnosis was 32.7±11.8yr, 24.4% were African American, 65.0% were premenopausal, and mean SDI±S.D. was 1.3±1.8. In the unadjusted and adjusted models controlling for significant univariate risk factors for osteoporosis, the reference group (Group 1) had significantly lower mean BMD T-scores at the hip and lumbar spine than groups having no disease damage (Groups 3 and 4) independent of CS use status. Similar hip and lumbar spine mean BMD T-scores were observed in women with disease damage with and without CS exposure (Groups 1 and 2). Conclusions. Women with SLE having disease damage and no CS use had BMD T-scores at the hip and lumbar spine similar to those of women with disease damage and prior CS use. These findings suggest an association between disease damage and lower BMD T-scores in women with SLE.

Original languageEnglish (US)
Pages (from-to)53-60
Number of pages8
JournalRheumatology
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2006

Keywords

  • Bone mineral density
  • Corticosteroids
  • Disease damage
  • Osteoporosis
  • SLE

ASJC Scopus subject areas

  • Rheumatology
  • Pharmacology (medical)

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