Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders

Richard M. Shore

doi:10.1007/s00247-022-05373-z

Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders

Richard M. Shore^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Phosphorus, predominantly in the form of inorganic phosphate PO₄⁻³, has many essential physiological functions. In the skeleton, phosphate and calcium form the mineral component and phosphate is also essential in regulating function of skeletal cells. Considerable advances have been made in our understanding of phosphate homeostasis since the recognition of fibroblast growth factor-23 (FGF23) as a bone-derived phosphaturic hormone. This second part of a two-part review of disorders of phosphate homeostasis in children covers hypophosphatemic and hyperphosphatemic disorders that are of interest to the pediatric radiologist, emphasizing, but not limited to, those related to abnormalities of FGF23 signaling.

Original language	English (US)
Pages (from-to)	2290-2305
Number of pages	16
Journal	Pediatric radiology
Volume	52
Issue number	12
DOIs	https://doi.org/10.1007/s00247-022-05373-z
State	Published - Nov 2022

Keywords

Bone
Children
Fibroblast growth factor-23
Hypophosphatemic rickets
Mineralization
Phosphate
Radiography

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Radiology Nuclear Medicine and imaging

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10.1007/s00247-022-05373-z

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title = "Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders",

abstract = "Phosphorus, predominantly in the form of inorganic phosphate PO4−3, has many essential physiological functions. In the skeleton, phosphate and calcium form the mineral component and phosphate is also essential in regulating function of skeletal cells. Considerable advances have been made in our understanding of phosphate homeostasis since the recognition of fibroblast growth factor-23 (FGF23) as a bone-derived phosphaturic hormone. This second part of a two-part review of disorders of phosphate homeostasis in children covers hypophosphatemic and hyperphosphatemic disorders that are of interest to the pediatric radiologist, emphasizing, but not limited to, those related to abnormalities of FGF23 signaling.",

keywords = "Bone, Children, Fibroblast growth factor-23, Hypophosphatemic rickets, Mineralization, Phosphate, Radiography",

author = "Shore, {Richard M.}",

note = "Funding Information: I would like to thank Aaron L. Friedman, MD, for his helpful advice. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

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doi = "10.1007/s00247-022-05373-z",

language = "English (US)",

volume = "52",

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journal = "Pediatric radiology",

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publisher = "Springer Verlag",

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T1 - Disorders of phosphate homeostasis in children, part 2

T2 - hypophosphatemic and hyperphosphatemic disorders

AU - Shore, Richard M.

N1 - Funding Information: I would like to thank Aaron L. Friedman, MD, for his helpful advice. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

PY - 2022/11

Y1 - 2022/11

N2 - Phosphorus, predominantly in the form of inorganic phosphate PO4−3, has many essential physiological functions. In the skeleton, phosphate and calcium form the mineral component and phosphate is also essential in regulating function of skeletal cells. Considerable advances have been made in our understanding of phosphate homeostasis since the recognition of fibroblast growth factor-23 (FGF23) as a bone-derived phosphaturic hormone. This second part of a two-part review of disorders of phosphate homeostasis in children covers hypophosphatemic and hyperphosphatemic disorders that are of interest to the pediatric radiologist, emphasizing, but not limited to, those related to abnormalities of FGF23 signaling.

AB - Phosphorus, predominantly in the form of inorganic phosphate PO4−3, has many essential physiological functions. In the skeleton, phosphate and calcium form the mineral component and phosphate is also essential in regulating function of skeletal cells. Considerable advances have been made in our understanding of phosphate homeostasis since the recognition of fibroblast growth factor-23 (FGF23) as a bone-derived phosphaturic hormone. This second part of a two-part review of disorders of phosphate homeostasis in children covers hypophosphatemic and hyperphosphatemic disorders that are of interest to the pediatric radiologist, emphasizing, but not limited to, those related to abnormalities of FGF23 signaling.

KW - Bone

KW - Children

KW - Fibroblast growth factor-23

KW - Hypophosphatemic rickets

KW - Mineralization

KW - Phosphate

KW - Radiography

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U2 - 10.1007/s00247-022-05373-z

DO - 10.1007/s00247-022-05373-z

M3 - Review article

C2 - 35536416

AN - SCOPUS:85129812021

SN - 0301-0449

VL - 52

SP - 2290

EP - 2305

JO - Pediatric radiology

JF - Pediatric radiology

IS - 12

ER -

Disorders of phosphate homeostasis in children, part 2: hypophosphatemic and hyperphosphatemic disorders

Abstract

Keywords

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