Dispersion due to wall interactions in microfluidic separation systems

Subhra Datta; Sandip Ghosal

doi:10.1063/1.2828098

Dispersion due to wall interactions in microfluidic separation systems

Subhra Datta^*, Sandip Ghosal

^*Corresponding author for this work

Mechanical Engineering

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The transport of a solute in a straight microchannel of axially variable cross-sectional shape in the presence of an inhomogeneous flow field and an adsorption-desorption process on the wall is studied, motivated by applications to capillary electrophoresis and open-channel capillary electrochromatography. An asymptotic approach based on the long time limit is adopted that reduces the problem to the solution of a one-dimensional transport equation. The reduced model is integrated numerically to study the effects of inhomogeneous electro-osmotic flow and adsorption-desorption kinetics on solute migration and dispersion in a rectangular microchannel. The accuracy of the asymptotic equations is checked by the direct numerical solution of the original three-dimensional transport problem.

Original language	English (US)
Article number	012103
Journal	Physics of Fluids
Volume	20
Issue number	1
DOIs	https://doi.org/10.1063/1.2828098
State	Published - Jan 2008

Keywords

Adsorption
Chemical analysis
Desorption
Microchannel flow

ASJC Scopus subject areas

Computational Mechanics
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering
Fluid Flow and Transfer Processes

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10.1063/1.2828098

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abstract = "The transport of a solute in a straight microchannel of axially variable cross-sectional shape in the presence of an inhomogeneous flow field and an adsorption-desorption process on the wall is studied, motivated by applications to capillary electrophoresis and open-channel capillary electrochromatography. An asymptotic approach based on the long time limit is adopted that reduces the problem to the solution of a one-dimensional transport equation. The reduced model is integrated numerically to study the effects of inhomogeneous electro-osmotic flow and adsorption-desorption kinetics on solute migration and dispersion in a rectangular microchannel. The accuracy of the asymptotic equations is checked by the direct numerical solution of the original three-dimensional transport problem.",

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author = "Subhra Datta and Sandip Ghosal",

note = "Funding Information: Support from the NSF under Grant No. CTS-0330604 is gratefully acknowledged. The authors are thankful to Dr. Neelesh A. Patankar for providing the computer code used for three-dimensional numerical solution of the transport equation.",

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AU - Datta, Subhra

AU - Ghosal, Sandip

N1 - Funding Information: Support from the NSF under Grant No. CTS-0330604 is gratefully acknowledged. The authors are thankful to Dr. Neelesh A. Patankar for providing the computer code used for three-dimensional numerical solution of the transport equation.

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N2 - The transport of a solute in a straight microchannel of axially variable cross-sectional shape in the presence of an inhomogeneous flow field and an adsorption-desorption process on the wall is studied, motivated by applications to capillary electrophoresis and open-channel capillary electrochromatography. An asymptotic approach based on the long time limit is adopted that reduces the problem to the solution of a one-dimensional transport equation. The reduced model is integrated numerically to study the effects of inhomogeneous electro-osmotic flow and adsorption-desorption kinetics on solute migration and dispersion in a rectangular microchannel. The accuracy of the asymptotic equations is checked by the direct numerical solution of the original three-dimensional transport problem.

AB - The transport of a solute in a straight microchannel of axially variable cross-sectional shape in the presence of an inhomogeneous flow field and an adsorption-desorption process on the wall is studied, motivated by applications to capillary electrophoresis and open-channel capillary electrochromatography. An asymptotic approach based on the long time limit is adopted that reduces the problem to the solution of a one-dimensional transport equation. The reduced model is integrated numerically to study the effects of inhomogeneous electro-osmotic flow and adsorption-desorption kinetics on solute migration and dispersion in a rectangular microchannel. The accuracy of the asymptotic equations is checked by the direct numerical solution of the original three-dimensional transport problem.

KW - Adsorption

KW - Chemical analysis

KW - Desorption

KW - Microchannel flow

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Dispersion due to wall interactions in microfluidic separation systems

Abstract

Keywords

ASJC Scopus subject areas

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