Dispersion due to wall interactions in microfluidic separation systems

Subhra Datta*, Sandip Ghosal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


The transport of a solute in a straight microchannel of axially variable cross-sectional shape in the presence of an inhomogeneous flow field and an adsorption-desorption process on the wall is studied, motivated by applications to capillary electrophoresis and open-channel capillary electrochromatography. An asymptotic approach based on the long time limit is adopted that reduces the problem to the solution of a one-dimensional transport equation. The reduced model is integrated numerically to study the effects of inhomogeneous electro-osmotic flow and adsorption-desorption kinetics on solute migration and dispersion in a rectangular microchannel. The accuracy of the asymptotic equations is checked by the direct numerical solution of the original three-dimensional transport problem.

Original languageEnglish (US)
Article number012103
JournalPhysics of Fluids
Issue number1
StatePublished - Jan 2008


  • Adsorption
  • Chemical analysis
  • Desorption
  • Microchannel flow

ASJC Scopus subject areas

  • Computational Mechanics
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering
  • Fluid Flow and Transfer Processes


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