Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

Noelle E. Younge*, Christopher B. Newgard, C. Michael Cotten, Ronald N. Goldberg, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, Thomas M. O’Connell, John F. Rawls, Patrick Casey Seed, Patricia L. Ashley

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.

Original languageEnglish (US)
Article number8167
JournalScientific reports
Volume9
Issue number1
DOIs
StatePublished - Dec 1 2019

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Extremely Premature Infants
Metabolome
Microbiota
Growth
Premature Infants
Fatty Acids
Veillonella
Metabolomics
Lipolysis
Enterobacteriaceae
Bacteria

ASJC Scopus subject areas

  • General

Cite this

Younge, N. E., Newgard, C. B., Cotten, C. M., Goldberg, R. N., Muehlbauer, M. J., Bain, J. R., ... Ashley, P. L. (2019). Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. Scientific reports, 9(1), [8167]. https://doi.org/10.1038/s41598-019-44547-y
Younge, Noelle E. ; Newgard, Christopher B. ; Cotten, C. Michael ; Goldberg, Ronald N. ; Muehlbauer, Michael J. ; Bain, James R. ; Stevens, Robert D. ; O’Connell, Thomas M. ; Rawls, John F. ; Seed, Patrick Casey ; Ashley, Patricia L. / Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. In: Scientific reports. 2019 ; Vol. 9, No. 1.
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Younge, NE, Newgard, CB, Cotten, CM, Goldberg, RN, Muehlbauer, MJ, Bain, JR, Stevens, RD, O’Connell, TM, Rawls, JF, Seed, PC & Ashley, PL 2019, 'Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure', Scientific reports, vol. 9, no. 1, 8167. https://doi.org/10.1038/s41598-019-44547-y

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. / Younge, Noelle E.; Newgard, Christopher B.; Cotten, C. Michael; Goldberg, Ronald N.; Muehlbauer, Michael J.; Bain, James R.; Stevens, Robert D.; O’Connell, Thomas M.; Rawls, John F.; Seed, Patrick Casey; Ashley, Patricia L.

In: Scientific reports, Vol. 9, No. 1, 8167, 01.12.2019.

Research output: Contribution to journalArticle

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