Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

Noelle E. Younge; Christopher B. Newgard; C. Michael Cotten; Ronald N. Goldberg; Michael J. Muehlbauer; James R. Bain; Robert D. Stevens; Thomas M. O’Connell; John F. Rawls; Patrick C. Seed; Patricia L. Ashley

doi:10.1038/s41598-019-44547-y

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

Noelle E. Younge^*, Christopher B. Newgard, C. Michael Cotten, Ronald N. Goldberg, Michael J. Muehlbauer, James R. Bain, Robert D. Stevens, Thomas M. O’Connell, John F. Rawls, Patrick C. Seed, Patricia L. Ashley

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.

Original language	English (US)
Article number	8167
Journal	Scientific reports
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41598-019-44547-y
State	Published - Dec 1 2019

Funding

This work was supported by the Gerber Foundation (to P.L.A.). The authors received support from the NIH (K12 HD043494 to N.E.Y.), the Jean and George Brumley Jr. Neonatal-Perinatal Research Institute, and Zeist Foundation.

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Younge, N. E., Newgard, C. B., Cotten, C. M., Goldberg, R. N., Muehlbauer, M. J., Bain, J. R., Stevens, R. D., O’Connell, T. M., Rawls, J. F., Seed, P. C., & Ashley, P. L. (2019). Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure. Scientific reports, 9(1), Article 8167. https://doi.org/10.1038/s41598-019-44547-y

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abstract = "Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.",

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Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

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